(2S)-2-[(3-chloro-4-cyanophenyl)amino]-4-[(1,1-dimethylethyl)oxy]-4-oxobutanoic acid

Base Information

Chemical Name:(2S)-2-[(3-chloro-4-cyanophenyl)amino]-4-[(1,1-dimethylethyl)oxy]-4-oxobutanoic acid
CAS No.:1006035-81-9
Molecular Formula:C₁₅H₁₇ClN₂O₄
Molecular Weight:324.764
Hs Code.:

Synonyms:(2S)-2-[(3-chloro-4-cyanophenyl)amino]-4-[(1,1-dimethylethyl)oxy]-4-oxobutanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-2-[(3-chloro-4-cyanophenyl)amino]-4-[(1,1-dimethylethyl)oxy]-4-oxobutanoic acid

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Technology Process of (2S)-2-[(3-chloro-4-cyanophenyl)amino]-4-[(1,1-dimethylethyl)oxy]-4-oxobutanoic acid

There total 1 articles about (2S)-2-[(3-chloro-4-cyanophenyl)amino]-4-[(1,1-dimethylethyl)oxy]-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 3057-74-7
L-Asp(t-Bu)

: 60702-69-4
2-chloro-4-fluorobenzonitrile

: 1006035-81-9
(2S)-2-[(3-chloro-4-cyanophenyl)amino]-4-[(1,1-dimethylethyl)oxy]-4-oxobutanoic acid

Guidance literature:: With sodium hydrogencarbonate; In water; dimethyl sulfoxide; at 95 ℃; for 15h;

Reference yield: 99.8%

: 1006035-81-9
(2S)-2-[(3-chloro-4-cyanophenyl)amino]-4-[(1,1-dimethylethyl)oxy]-4-oxobutanoic acid

: 1006035-83-1
1,1-dimethylethyl (3S)-3-[(3-chloro-4-cyanophenyl)amino]-4-hydroxybutanoate

Guidance literature:: (2S)-2-[(3-chloro-4-cyanophenyl)amino]-4-[(1,1-dimethylethyl)oxy]-4-oxobutanoic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at -65 ℃; for 1h; Cooling with acetone-dry ice;

With sodium tetrahydroborate; In tetrahydrofuran; water; at -70 - 0 ℃; for 1h;

With hydrogenchloride; water; In tetrahydrofuran; ethyl acetate; at 20 ℃; pH=2.5; Product distribution / selectivity;