3057-74-7

Basic information

• Product Name: L-Aspartic acid 4-tert-butyl ester
• Synonyms: ASPARTIC ACID BETA T-BUTYL ESTER MONOHYDRATE;ASPARTIC ACID(OTBU);H-ASP(OBUT)-OH;H-ASP(OTBU)-OH;H-L-ASP(OTBU)-OH;H-L-ASP(TBU)-OH H2O;L-ASPARTIC ACID 4-TERT-BUTYL ESTER;L-ASPARTIC ACID B-TERT-BUTYL ESTER
• CAS NO: 3057-74-7
• Molecular Formula: C₈H₁₅NO₄
• Molecular Weight: 189.21
• EINECS: 221-292-8
• Product Categories: Amino Acids Derivatives;Amino Acids;Aspartic acid [Asp, D];Amino Acids and Derivatives;Amino Acid Derivatives;Aspartic Acid;Peptide Synthesis
• Mol File: 3057-74-7.mol
• Article Data: 11

Chemical Properties

• Melting Point: 220°C (dec.)
• Boiling Point: 318.7 °C at 760 mmHg
• Flash Point: 146.5 °C
• Appearance: /
• Density: 1.162 g/cm³
• Vapor Pressure: 7.48E-05mmHg at 25°C
• Refractive Index: 1.475
• Storage Temp.: 2-8°C
• Solubility: Methanol (Slightly), Water (Slightly, Sonicated)
• PKA: 2.19±0.23(Predicted)
• Stability: Hygroscopic
• BRN: 4671089
• CAS DataBase Reference: L-Aspartic acid 4-tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Aspartic acid 4-tert-butyl ester(3057-74-7)
• EPA Substance Registry System: L-Aspartic acid 4-tert-butyl ester(3057-74-7)

Safety Data

• Statements: 36/37/38
• Safety Statements: 22-24/25-44-35-28-7-4
• WGK Germany: 3
• Hazardous Substances Data: 3057-74-7(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

L-Aspartic acid 4-tert-butyl ester is a protected form of L-Aspartic acid (A790024). L-Aspartic acid is a nonessential amino acid that is used to biosynthesize other amino acids within the human body. L-Aspartic acid also increases membrane conductance of mammalian neurons by voltage-dependent means, causing depolarization and nerve impulses that travel to key areas of the central nervous system.

InChI:InChI=1/C8H15NO4/c1-8(2,3)13-6(10)4-5(9)7(11)12/h5H,4,9H2,1-3H3,(H,11,12)/t5-/m1/s1

Upstream product

• 63276-59-5 L-aspartic acid β-tert-butyl ester α-ethyl ester 
• 71989-14-5 Fmoc-(tBu)Asp-OH 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 115-11-7 isobutene 
• 1791-13-5 L-aspartic acid di-tert-butyl ester hydrochloride 
• 127556-07-4 (2R)-N-<(2S)-2-<amino>-3-<(tert-butyl)oxycarbonyl>propan-1-oyl>bornane-10,2-sultam 
• 2131-29-5 (S)-1-benzyl-4-tert-butyl 2-aminosuccinate 
• 5545-52-8 Z-D(tBu)-OH 
• 27486-72-2 Z-L-Asp(β-O-t-Bu)-ONb 
• 36702-55-3 (S)-2-Benzyloxycarbonylamino-succinic acid 4-tert-butyl ester 1-ethyl ester 

Downstream Products

• 1676-90-0 Boc-Asp(OtBu)-OH 
• 5545-52-8 Z-D(tBu)-OH 
• 71989-14-5 Fmoc-(tBu)Asp-OH 
• 152548-66-8 (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-4-(tert-butoxy)-4-oxobutanoic acid 
• 482632-06-4 2-(9-phenyl-9H-fluoren-9-ylamino)-succinic acid 4-tert-butyl ester 
• 117833-17-7 α-benzyl,β-tert-butyl ester of N-acetylaspartic acid 
• 1245517-67-2 C₂₅H₃₁N₅O₁₂ 
• 1245517-46-7 Ac-Asn(β-GlcNAc)-Asp-Ala-Tyr-Ser-OH 
• 1245517-30-9 H-(Dmb)-Asp(OtBu)-OH 
• 1258739-97-7 (S)-4-tert-butoxy-2-(4-methylphenylsulfonamido)-4-oxobutanoic acid 
• 131668-52-5 Z-Gly-Asp(OBu)-OH 
• 214473-41-3 (S)-2-Benzoylamino-succinic acid 4-tert-butyl ester 

Relevant articles and documents

Preparation of the beta-tert-butyl ester of L-asparaginic acid.

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Preparation method of N -fluorenylmethoxycarbonyl - L -aspartic -4 -tert-butyl ester

The invention relates to the technical field of organic synthesis, in particular to a preparation method of a fluorenylmethoxycarbonyl - aspartic -4 - tert-butyl ester, which comprises the following specific steps: L - aspartic acid is used as a starting raw material, L - aspartic acid internal anhydride hydrochloride is obtained through dehydration treatment of phosphorus trichloride. L- Aspartic acid ester hydrochloride and ethanol were subjected to alcoholysis to obtain L -aspartate hydrochloride. The transesterification reaction L-aspartate and tert-butyl ester gives L -butyl-1 -ethyl-4 -butyl acrylate. Further hydrolysis L-butyl-1 - ethyl ester -4 - gives L -butyl-4 -tert-butyl ester. The L-aspartate -4 - tert-butyl ester is reacted with the fluorenylmethoxycarbonyl reagent to obtain the target product fluorenylmethoxycarbonyl - aspartic -4 -tert-butyl ester. The preparation method of the fluorenylmethoxycarbonyl - aspartic -4 - tert-butyl ester provided by the invention is safe and environment-friendly in production process and suitable for industrial large-scale production.

Reliable and safe, gram-scale hydrogenation and hydrogenolysis of O-benzyl ether groups with in situ Pd0/C catalyst

Hydrogenation of alkenes, alkynes, and hydrogenolysis of O-benzyl ethers with Pd0/C catalyst generated in situ can be readily scaled up under safer conditions than with traditional procedures. The precise control of the palladium loading and the mild conditions developed allow the formation of a very active and reliable Pd0/C catalyst, leading to highly reproducible results. Georg Thieme Verlag Stuttgart - New York.