(S)-2-((S)-2-Acetylsulfanylmethyl-4-phenyl-butyrylamino)-4-methylsulfanyl-butyric acid ethyl ester

Base Information

Chemical Name:(S)-2-((S)-2-Acetylsulfanylmethyl-4-phenyl-butyrylamino)-4-methylsulfanyl-butyric acid ethyl ester
CAS No.:156792-21-1
Molecular Formula:C₂₀H₂₉NO₄S₂
Molecular Weight:411.587
Hs Code.:

Synonyms:(S)-2-((S)-2-Acetylsulfanylmethyl-4-phenyl-butyrylamino)-4-methylsulfanyl-butyric acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-((S)-2-Acetylsulfanylmethyl-4-phenyl-butyrylamino)-4-methylsulfanyl-butyric acid ethyl ester

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Technology Process of (S)-2-((S)-2-Acetylsulfanylmethyl-4-phenyl-butyrylamino)-4-methylsulfanyl-butyric acid ethyl ester

There total 5 articles about (S)-2-((S)-2-Acetylsulfanylmethyl-4-phenyl-butyrylamino)-4-methylsulfanyl-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 2899-36-7
L-methionine ethyl ester monohydrochloride

: 116112-44-8
2-[(acetylthio)methyl]-4-phenylbutanoic acid

: 156792-22-2
(S)-2-((R)-2-Acetylsulfanylmethyl-4-phenyl-butyrylamino)-4-methylsulfanyl-butyric acid ethyl ester

: 156792-21-1
(S)-2-((S)-2-Acetylsulfanylmethyl-4-phenyl-butyrylamino)-4-methylsulfanyl-butyric acid ethyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; for 20h;
DOI:10.1021/jm00041a026

Reference yield:

: 103-63-9
1-phenyl-2-bromoethane

: 156792-21-1
(S)-2-((S)-2-Acetylsulfanylmethyl-4-phenyl-butyrylamino)-4-methylsulfanyl-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Na / 1.) EtOH, from 0 to 5 deg C, 10 min, 2.) EtOH, reflux, 4 h

2: 1.) n-BuLi, diisopropylamine / 1.) THF, -60 deg C, 10 min, 2.) THF, a) RT, 1h, b) reflux, 1 h

3: 47 percent / 72 h

4: 52 percent / CF₃COOH / 0.5 h

5: 17 percent / EDC, HOBT, N-methylmorpholine / dimethylformamide / 20 h

With 4-methyl-morpholine; n-butyllithium; sodium; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; diisopropylamine; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm00041a026

Reference yield:

: 84793-30-6
1,1-dimethylethyl α-methylenebenzenebutanoate

: 156792-21-1
(S)-2-((S)-2-Acetylsulfanylmethyl-4-phenyl-butyrylamino)-4-methylsulfanyl-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 47 percent / 72 h

2: 52 percent / CF₃COOH / 0.5 h

3: 17 percent / EDC, HOBT, N-methylmorpholine / dimethylformamide / 20 h

With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm00041a026