84793-30-6

Upstream product

• 1694-31-1 tert-butyl acetoacetate 
• 103-63-9 1-phenyl-2-bromoethane 
• 53913-96-5 tert-butyl 2-(bromomethyl)acrylate 
• 98-86-2 acetophenone 

Downstream Products

• 156757-40-3 1,1-dimethylethyl α-<((R,S)-acetylthio)methyl>benzenebutanoate 
• 168081-19-4 1-[2-(tert-butoxycarbonyl)-4-phenylbutyl]cyclopentane-1-carboxylic acid 
• 156792-21-1 (S)-2-((S)-2-Acetylsulfanylmethyl-4-phenyl-butyrylamino)-4-methylsulfanyl-butyric acid ethyl ester 
• 156792-22-2 (S)-2-((R)-2-Acetylsulfanylmethyl-4-phenyl-butyrylamino)-4-methylsulfanyl-butyric acid ethyl ester 
• 116112-44-8 2-[(acetylthio)methyl]-4-phenylbutanoic acid 

Relevant academic research and scientific papers

Base-Promoted C-C Bond Activation Enables Radical Allylation with Homoallylic Alcohols

The Cα-Cβ bond in homoallylic alcohols can be activated under basic conditions, qualifying these nonstrained acyclic systems as radical allylation reagents. This reactivity is exemplified by photoinitiated (with visible light and/or

Pharmaceuticals which promote gastrointestinal blood circulation

The use is described of compounds of the general formula I STR1 wherein R1 represents a phenyl-lower alkyl group which can optionally be substituted in the phenyl ring by lower alkyl, lower alkoxy or halogen, or represents a naphthyl-lower alkyl group, R2 denotes hydrogen or a biolabile ester-forming group, and R3 denotes hydrogen or a biolabile ester-forming group, and physiologically acceptable salts of the acids of formula I for preparing pharmaceutical compositions for the treatment and/or prophylaxis of gastrointestinal blood circulation disturbances.

BENZAZEPINE-, BENZOXAZEPINE- AND BENZOTHIAZEPINE-N-ACETIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Compounds with neutral endopeptidase (NEP) inhibitory activity corresponding to the formula I STR1 in which R 1 is a lower alkoxy-lower-alkyl group whose lower alkoxy radical is substituted by a lower alkoxy group, or a phenyl-lower-alkyl or phenyloxy-lower-alkyl group which can optionally be substituted in the phenyl ring by lower alkyl, lower alkoxy or halogen, or a naphthyl-lower-alkyl group, A is CH 2, O or S,R 2 is hydrogen or halogen,R. sup.3 is hydrogen or halogen,R 4 is hydrogen or a group forming a biolabile ester, andR 5 is hydrogen or a group forming a biolabile ester, and the physiologically acceptable acid addition salts thereof.

Mercaptoacyl amino acid inhibitors of atriopeptidase. 1. Structure- activity relationship studies of methionine and S-alkylcysteine derivatives

A broad series of N-(3-mercaptoacyl) amino acid derivatives was evaluated for their ability to inhibit atriopeptidase (neutral endopeptidase, EC 3.4.24.11) in vitro and in vivo. Structural parameters studied were (i) the substituent on the 2-position of the 3-mercaptopropionyl moiety, (ii) the amino acid component, (iii) the S-terminal derivative, and (iv) the C- terminal derivative. Optimum activity was observed for derivatives of methionine and S-alkylcysteines. N-[3-Mercapto-2(S)-[(2- methylphenyl)methyl]-1-oxopropyl]-L-methionine was identified as a highly effective inhibitor of atriopeptidase meriting evaluation as a potential cardiovascular therapeutic agent.

ANTIHYPERTENSIVE PROLINE DERIVATIVES

The invention relates to urea compounds which are useful as antihypertensives.