ethyl 3-(3,4-difluorophenyl)-2-(methylsulfanyl)-3,4,5,6-tetrahydropyridine-3-carboxylate

Base Information

Chemical Name:ethyl 3-(3,4-difluorophenyl)-2-(methylsulfanyl)-3,4,5,6-tetrahydropyridine-3-carboxylate
CAS No.:1363145-28-1
Molecular Formula:C₁₅H₁₇F₂NO₂S
Molecular Weight:313.368
Hs Code.:

Synonyms:ethyl 3-(3,4-difluorophenyl)-2-(methylsulfanyl)-3,4,5,6-tetrahydropyridine-3-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 3-(3,4-difluorophenyl)-2-(methylsulfanyl)-3,4,5,6-tetrahydropyridine-3-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of ethyl 3-(3,4-difluorophenyl)-2-(methylsulfanyl)-3,4,5,6-tetrahydropyridine-3-carboxylate

There total 5 articles about ethyl 3-(3,4-difluorophenyl)-2-(methylsulfanyl)-3,4,5,6-tetrahydropyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1363144-43-7
ethyl 3-(3,4-difluorophenyl)-2-thioxopiperidine-3-carboxylate

: 74-88-4
methyl iodide

: 1363145-28-1
ethyl 3-(3,4-difluorophenyl)-2-(methylsulfanyl)-3,4,5,6-tetrahydropyridine-3-carboxylate

Guidance literature:: In acetonitrile; at 20 - 50 ℃; for 3h;

Reference yield:

: 131505-78-7
diethyl (3,4-difluorophenyl)propanedioate

: 1363145-28-1
ethyl 3-(3,4-difluorophenyl)-2-(methylsulfanyl)-3,4,5,6-tetrahydropyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium ethanolate / tert-butyl alcohol / 0.5 h / 20 - 40 °C / Inert atmosphere

1.2: 20 °C

2.1: hydrogen; ammonia / Raney cobalt / ethanol / 72 h / 20 °C

3.1: Lawessons reagent / toluene / 4 h / 20 - 110 °C

4.1: acetonitrile / 3 h / 20 - 50 °C

With Lawessons reagent; ammonia; hydrogen; sodium ethanolate; Raney cobalt; In ethanol; toluene; acetonitrile; tert-butyl alcohol;

Reference yield:

: 129409-55-8
ethyl 2-(3,4-difluorophenyl)acetate

: 1363145-28-1
ethyl 3-(3,4-difluorophenyl)-2-(methylsulfanyl)-3,4,5,6-tetrahydropyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C / Reflux

2.1: sodium ethanolate / tert-butyl alcohol / 0.5 h / 20 - 40 °C / Inert atmosphere

2.2: 20 °C

3.1: hydrogen; ammonia / Raney cobalt / ethanol / 72 h / 20 °C

4.1: Lawessons reagent / toluene / 4 h / 20 - 110 °C

5.1: acetonitrile / 3 h / 20 - 50 °C

With Lawessons reagent; ammonia; hydrogen; sodium ethanolate; sodium hydride; Raney cobalt; In tetrahydrofuran; ethanol; toluene; acetonitrile; mineral oil; tert-butyl alcohol;