N-{[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-1-({3-[({[6-fluoro-3'-(1-piperazinylmethyl)-3-biphenylyl]methyl}amino)carbonyl]phenyl}sulfonyl)-4-piperidinecarboxamide

Base Information

• Chemical Name: N-{[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-1-({3-[({[6-fluoro-3'-(1-piperazinylmethyl)-3-biphenylyl]methyl}amino)carbonyl]phenyl}sulfonyl)-4-piperidinecarboxamide
• CAS No.: 1179344-58-1
• Molecular Formula: C₄₇H₅₈FN₉O₅S
• Molecular Weight: 880.099
• Mol file: 1179344-58-1.mol

Synonyms:N-{[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-1-({3-[({[6-fluoro-3'-(1-piperazinylmethyl)-3-biphenylyl]methyl}amino)carbonyl]phenyl}sulfonyl)-4-piperidinecarboxamide

Chemical Property of N-{[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-1-({3-[({[6-fluoro-3'-(1-piperazinylmethyl)-3-biphenylyl]methyl}amino)carbonyl]phenyl}sulfonyl)-4-piperidinecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-1-({3-[({[6-fluoro-3'-(1-piperazinylmethyl)-3-biphenylyl]methyl}amino)carbonyl]phenyl}sulfonyl)-4-piperidinecarboxamide

There total 4 articles about N-{[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-1-({3-[({[6-fluoro-3'-(1-piperazinylmethyl)-3-biphenylyl]methyl}amino)carbonyl]phenyl}sulfonyl)-4-piperidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C52H66FN9O7S → N-{[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-1-({3-[({[6-fluoro-3'-(1-piperazinylmethyl)-3-biphenylyl]methyl}amino)carbonyl]phenyl}sulfonyl)-4-piperidinecarboxamide (1179344-58-1)

Guidance literature:

C₅₂H₆₆FN₉O₇S; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

amine cartridge;

Reference yield:

(3-((4-(tert-butoxycarbonyl)piperazin-1-yl)methyl)phenyl)boronic acid (865314-28-9) → N-{[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-1-({3-[({[6-fluoro-3'-(1-piperazinylmethyl)-3-biphenylyl]methyl}amino)carbonyl]phenyl}sulfonyl)-4-piperidinecarboxamide (1179344-58-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: water; potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.25 h / 150 °C / Microwave irradiation

2.1: potassium carbonate / tetrahydrofuran; water / 26 h / 20 °C

2.2: 18 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.2: amine cartridge

With water; potassium carbonate; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 1.1: Suzuki Coupling;

Reference yield:

3-Formylphenylboronic acid (87199-16-4) → N-{[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-1-({3-[({[6-fluoro-3'-(1-piperazinylmethyl)-3-biphenylyl]methyl}amino)carbonyl]phenyl}sulfonyl)-4-piperidinecarboxamide (1179344-58-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium tris(acetoxy)borohydride / dichloromethane / 17 h / 20 °C

2.1: water; potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.25 h / 150 °C / Microwave irradiation

3.1: potassium carbonate / tetrahydrofuran; water / 26 h / 20 °C

3.2: 18 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.2: amine cartridge

With water; sodium tris(acetoxy)borohydride; potassium carbonate; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 2.1: Suzuki Coupling;

upstream raw materials:

(3-((4-(tert-butoxycarbonyl)piperazin-1-yl)methyl)phenyl)boronic acid

1,1-dimethylethyl 4-{[5'-(aminomethyl)-2'-fluoro-3-biphenylyl]methyl}-1-piperazinecarboxylate

3-Formylphenylboronic acid