(3-((4-(tert-butoxycarbonyl)piperazin-1-yl)Methyl)phenyl)boronic acid

Base Information

• Chemical Name: (3-((4-(tert-butoxycarbonyl)piperazin-1-yl)Methyl)phenyl)boronic acid
• CAS No.: 865314-28-9
• Molecular Formula: C16H25BN2O4
• Molecular Weight: 320.196
• Mol file: 865314-28-9.mol

Synonyms:(3-((4-(tert-butoxycarbonyl)piperazin-1-yl)Methyl)phenyl)boronic acid

Chemical Property of (3-((4-(tert-butoxycarbonyl)piperazin-1-yl)Methyl)phenyl)boronic acid

Chemical Property:

• Boiling Point: 472.0±55.0 °C(Predicted)
• PKA: 8.51±0.10(Predicted)
• PSA: 73.24000
• Density: 1.19±0.1 g/cm3(Predicted)
• LogP: 0.29490

Purity/Quality:

99% ^*data from raw suppliers

(3-((4-(tert-Butoxycarbonyl)piperazin-1-yl)methyl)phenyl)boronic acid 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3-((4-(tert-butoxycarbonyl)piperazin-1-yl)Methyl)phenyl)boronic acid

There total 3 articles about (3-((4-(tert-butoxycarbonyl)piperazin-1-yl)Methyl)phenyl)boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-Formylphenylboronic acid (87199-16-4) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → (3-((4-(tert-butoxycarbonyl)piperazin-1-yl)methyl)phenyl)boronic acid (865314-28-9)

Guidance literature:

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 17h;

Reference yield:

C18H29BN2O4 → (3-((4-(tert-butoxycarbonyl)piperazin-1-yl)methyl)phenyl)boronic acid (865314-28-9)

Guidance literature:

With water; ammonium chloride; In tetrahydrofuran; hexane; at 20 ℃;

Reference yield:

tert-butyl 4-(3-bromobenzyl)piperazine-1-carboxylate (865314-27-8) → (3-((4-(tert-butoxycarbonyl)piperazin-1-yl)methyl)phenyl)boronic acid (865314-28-9)

Guidance literature:

tert-butyl 4-(3-bromobenzyl)piperazine-1-carboxylate; With n-butyllithium; In tetrahydrofuran; at -70 ℃; for 0.666667h;

With Trimethyl borate; In tetrahydrofuran; at 20 ℃;

upstream raw materials:

tert-butyl 4-(3-bromobenzyl)piperazine-1-carboxylate

3-Formylphenylboronic acid

1-t-Butoxycarbonylpiperazine

Downstream raw materials:

1,1-dimethylethyl 4-[(5'-{[({3-[({[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}amino)carbonyl]-phenyl}methyl)(methyl)amino]-methyl}-2'-fluoro-3-biphenylyl)methyl]-1-piperazinecarboxylate

N-{[1,6-diethyl-4-(tetrahydro-1H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-2-(3'-(1-piperazinylmethyl)-3-biphenylyl)acetamide

N-{[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-1-({3-[({[6-fluoro-3'-(1-piperazinylmethyl)-3-biphenylyl]methyl}amino)carbonyl]phenyl}sulfonyl)-4-piperidinecarboxamide

2-[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-[(3'-{[1-piperazinyl]methyl}-3-biphenylyl)methyl]acetamide trifluoroacetate