tert-butyl (2S,3R,αR)-3-(N-benzyl-N-α-methylbenzylamino)-2-methylpentanoate

Base Information

Chemical Name:tert-butyl (2S,3R,αR)-3-(N-benzyl-N-α-methylbenzylamino)-2-methylpentanoate
CAS No.:158659-39-3
Molecular Formula:C₂₅H₃₅NO₂
Molecular Weight:381.558
Hs Code.:

Synonyms:tert-butyl (2S,3R,αR)-3-(N-benzyl-N-α-methylbenzylamino)-2-methylpentanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (2S,3R,αR)-3-(N-benzyl-N-α-methylbenzylamino)-2-methylpentanoate

Chemical Property:

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Technology Process of tert-butyl (2S,3R,αR)-3-(N-benzyl-N-α-methylbenzylamino)-2-methylpentanoate

There total 5 articles about tert-butyl (2S,3R,αR)-3-(N-benzyl-N-α-methylbenzylamino)-2-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 38235-77-7
(R)-N-benzyl-1-phenylethylamine

: 158659-41-7
tert-butyl (E)-2-methylpent-2-enoate

: 158659-39-3
tert-butyl (2S,3R,αR)-3-(N-benzyl-N-α-methylbenzylamino)-2-methylpentanoate

Guidance literature:: With n-butyllithium;
DOI:10.1021/ja001334r

Reference yield: 65.0%

: lithium benzyl-(R)-1-phenylethylamide

: 158659-41-7
tert-butyl (E)-2-methylpent-2-enoate

: 158659-39-3
tert-butyl (2S,3R,αR)-3-(N-benzyl-N-α-methylbenzylamino)-2-methylpentanoate

Guidance literature:: With 2,6-di-tert-butylphenol; 1.) toluene, -78 - -30 deg C, 3 h, 2.) THF, RT;

Reference yield:

: 20487-40-5
tert-butyl propionate

: 158659-39-3
tert-butyl (2S,3R,αR)-3-(N-benzyl-N-α-methylbenzylamino)-2-methylpentanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 26.2 g / LDA / tetrahydrofuran / 2 h / -78 °C

2: 27.2 g / triethylamine / CH₂Cl₂ / 2 h / Ambient temperature

3: DBU / tetrahydrofuran / 16 h / Ambient temperature

4: 65 percent / 2.) 2,6-di-tert-butylphenol / 1.) toluene, -78 - -30 deg C, 3 h, 2.) THF, RT

With 2,6-di-tert-butylphenol; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;