Methyl 3-[4-(5-bromo-3,3-dimethyl-2-oxo-2,3-dihydroindol-1-ylmethoxy)phenyl]hex-4-ynoate

Base Information

• Chemical Name: Methyl 3-[4-(5-bromo-3,3-dimethyl-2-oxo-2,3-dihydroindol-1-ylmethoxy)phenyl]hex-4-ynoate
• CAS No.: 1353043-41-0
• Molecular Formula: C₂₄H₂₄BrNO₄
• Molecular Weight: 470.363
• Mol file: 1353043-41-0.mol

Synonyms:Methyl 3-[4-(5-bromo-3,3-dimethyl-2-oxo-2,3-dihydroindol-1-ylmethoxy)phenyl]hex-4-ynoate

Chemical Property of Methyl 3-[4-(5-bromo-3,3-dimethyl-2-oxo-2,3-dihydroindol-1-ylmethoxy)phenyl]hex-4-ynoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl 3-[4-(5-bromo-3,3-dimethyl-2-oxo-2,3-dihydroindol-1-ylmethoxy)phenyl]hex-4-ynoate

There total 3 articles about Methyl 3-[4-(5-bromo-3,3-dimethyl-2-oxo-2,3-dihydroindol-1-ylmethoxy)phenyl]hex-4-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-(4-hydroxyphenyl-1-propynyl)propanoate (865234-02-2) + n-heptane (142-82-5) + 5-bromo-1-hydroxymethyl-3,3-dimethyl-1,3-dihydroindol-2-one (1353043-40-9) + triphenylphosphine (603-35-0) + diethylazodicarboxylate (1972-28-7,218603-74-8) → Methyl 3-[4-(5-bromo-3,3-dimethyl-2-oxo-2,3-dihydroindol-1-ylmethoxy)phenyl]hex-4-ynoate (1353043-41-0)

Guidance literature:

In tetrahydrofuran; water; ethyl acetate;

Reference yield:

5-bromo-3,3-dimethyl-1,3-dihydro-2H-indol-2-one (120902-45-6) → Methyl 3-[4-(5-bromo-3,3-dimethyl-2-oxo-2,3-dihydroindol-1-ylmethoxy)phenyl]hex-4-ynoate (1353043-41-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / ethyl acetate; water; mineral oil; N-methyl-acetamide

2: hydrogen bromide / ethyl acetate; acetic acid; ice-water

3: ethyl acetate; water; tetrahydrofuran

With sodium hydride; hydrogen bromide; In tetrahydrofuran; N-methyl-acetamide; ice-water; water; acetic acid; ethyl acetate; mineral oil;

Reference yield:

5-bromo-3,3-dimethyl-2-oxo-2,3-dihydroindol-1-ylmethyl 2,2-dimethylpropionate (1353043-39-6) → Methyl 3-[4-(5-bromo-3,3-dimethyl-2-oxo-2,3-dihydroindol-1-ylmethoxy)phenyl]hex-4-ynoate (1353043-41-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen bromide / ethyl acetate; acetic acid; ice-water

2: ethyl acetate; water; tetrahydrofuran

With hydrogen bromide; In tetrahydrofuran; ice-water; water; acetic acid; ethyl acetate;

upstream raw materials:

methyl 3-(4-hydroxyphenyl-1-propynyl)propanoate

n-heptane

5-bromo-1-hydroxymethyl-3,3-dimethyl-1,3-dihydroindol-2-one

triphenylphosphine

Downstream raw materials:

3-[4-(5-Bromo-3,3-dimethyl-2-oxo-2,3-dihydroindol-1-ylmethoxy)phenyl]hex-4-ynoic acid