(2S,4S)-pentafluorophenyl 4-(4-methoxy-3-(3-methoxypropoxy)benzyl)-2-(benzyloxycarbonylamino)-5-methylhexanoate

Base Information

Chemical Name:(2S,4S)-pentafluorophenyl 4-(4-methoxy-3-(3-methoxypropoxy)benzyl)-2-(benzyloxycarbonylamino)-5-methylhexanoate
CAS No.:913971-68-3
Molecular Formula:C₃₃H₃₆F₅NO₇
Molecular Weight:653.643
Hs Code.:

Synonyms:(2S,4S)-pentafluorophenyl 4-(4-methoxy-3-(3-methoxypropoxy)benzyl)-2-(benzyloxycarbonylamino)-5-methylhexanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4S)-pentafluorophenyl 4-(4-methoxy-3-(3-methoxypropoxy)benzyl)-2-(benzyloxycarbonylamino)-5-methylhexanoate

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Technology Process of (2S,4S)-pentafluorophenyl 4-(4-methoxy-3-(3-methoxypropoxy)benzyl)-2-(benzyloxycarbonylamino)-5-methylhexanoate

There total 1 articles about (2S,4S)-pentafluorophenyl 4-(4-methoxy-3-(3-methoxypropoxy)benzyl)-2-(benzyloxycarbonylamino)-5-methylhexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 900811-41-8
(2S,4S)-2-[[(phenylmethoxy)carbonyl]amino]-4-methoxy-3-(3-methoxypropoxy)-γ-(1-methylethyl)benzenepentanoic acid

: 771-61-9
2,3,4,5,6-pentafluorophenol

: 913971-68-3
(2S,4S)-pentafluorophenyl 4-(4-methoxy-3-(3-methoxypropoxy)benzyl)-2-(benzyloxycarbonylamino)-5-methylhexanoate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 1h;
DOI:10.1021/jo061299s

Reference yield: 77.0%

: 913971-68-3
(2S,4S)-pentafluorophenyl 4-(4-methoxy-3-(3-methoxypropoxy)benzyl)-2-(benzyloxycarbonylamino)-5-methylhexanoate

: 497-25-6
dimethylenecyclourethane

: 913971-69-4
benzyl (2S,4S)-4-(4-methoxy-3-(3-methoxypropoxy)benzyl)-5-methyl-1-oxo-1-(2-oxooxazolidin-3-yl)hexan-2-ylcarbamate

Guidance literature:: With trimethylaluminum; In dichloromethane; toluene; at 20 ℃; for 96h;
DOI:10.1021/jo061299s

Reference yield:

: 913971-68-3
(2S,4S)-pentafluorophenyl 4-(4-methoxy-3-(3-methoxypropoxy)benzyl)-2-(benzyloxycarbonylamino)-5-methylhexanoate

: ethyl (5S,7S)-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-5-(benzyloxycarbonylamino)-2-isopropyl-8-methyl-4-oxononanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / AlMe₃ / CH₂Cl₂; toluene / 96 h / 20 °C

2: 52 percent / samarium diiodide; water / tetrahydrofuran / 48 h / -78 °C

With samarium diiodide; water; trimethylaluminum; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jo061299s