4-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]-3-methyl-1H-pyrrolo[2,3-d]-pyridazine-2-carboxylic acid

Base Information

Chemical Name:4-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]-3-methyl-1H-pyrrolo[2,3-d]-pyridazine-2-carboxylic acid
CAS No.:944482-72-8
Molecular Formula:C₂₁H₁₆ClFN₄O₃
Molecular Weight:426.834
Hs Code.:

Synonyms:4-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]-3-methyl-1H-pyrrolo[2,3-d]-pyridazine-2-carboxylic acid

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Chemical Property of 4-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]-3-methyl-1H-pyrrolo[2,3-d]-pyridazine-2-carboxylic acid

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Technology Process of 4-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]-3-methyl-1H-pyrrolo[2,3-d]-pyridazine-2-carboxylic acid

There total 1 articles about 4-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]-3-methyl-1H-pyrrolo[2,3-d]-pyridazine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 944482-71-7
C₂₃H₂₀ClFN₄O₃

: 944482-72-8
4-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]-3-methyl-1H-pyrrolo[2,3-d]-pyridazine-2-carboxylic acid

Guidance literature:: C₂₃H₂₀ClFN₄O₃; With sodium hydroxide; In ethanol; Reflux;

With hydrogenchloride; In water; pH=1;
DOI:10.1016/j.bmcl.2009.09.038

Reference yield: 30.2%

: 2038-03-1
4-(2-AMINOETHYL)MORPHOLINE

: 944482-72-8
4-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]-3-methyl-1H-pyrrolo[2,3-d]-pyridazine-2-carboxylic acid

: 944482-18-2
4-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]-3-methyl-1H-pyrrolo[2,3-d]-pyridazine-2-(2-morpholin-4-yl-ethyl)-formamide

Guidance literature:: 4-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]-3-methyl-1H-pyrrolo[2,3-d]-pyridazine-2-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

4-(2-AMINOETHYL)MORPHOLINE; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.bmcl.2009.09.038

Reference yield:

: 934-98-5
2-(4-methylpiperazin-1-yl)ethylamine

: 944482-72-8
4-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]-3-methyl-1H-pyrrolo[2,3-d]-pyridazine-2-carboxylic acid

: 944482-23-9
C₂₈H₃₁ClFN₇O₂

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.bmcl.2009.09.038