944482-71-7Relevant articles and documents
Synthesis and biological evaluation of pyrrolopyridazine derivatives as novel HER-2 tyrosine kinase inhibitors
Tang, Peng Cho,Feng, Jun,Huang, Li,Xu, Zhe,Cheng, Ling,Zhang, Xu,Zhang, Lei,Hu, Bing
scheme or table, p. 6437 - 6440 (2010/06/11)
A series of novel pyrrolopyridazine derivatives have been discovered to be HER-2 inhibitors. These compounds selectively inhibited HER-2 kinase activity at low nanomolar concentrations. Compound 7d was identified as a potent HER-2 inhibitor with an IC50 of 4 nM.