tert-butyl 3-(1-(3-((hydroxydimethylsilyl)methyl)benzoyl)piperidin-4-yl)benzylcarbamate

Base Information

Chemical Name:tert-butyl 3-(1-(3-((hydroxydimethylsilyl)methyl)benzoyl)piperidin-4-yl)benzylcarbamate
CAS No.:1431289-50-7
Molecular Formula:C₂₇H₃₈N₂O₄Si
Molecular Weight:482.695
Hs Code.:

Synonyms:tert-butyl 3-(1-(3-((hydroxydimethylsilyl)methyl)benzoyl)piperidin-4-yl)benzylcarbamate

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Chemical Property of tert-butyl 3-(1-(3-((hydroxydimethylsilyl)methyl)benzoyl)piperidin-4-yl)benzylcarbamate

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Technology Process of tert-butyl 3-(1-(3-((hydroxydimethylsilyl)methyl)benzoyl)piperidin-4-yl)benzylcarbamate

There total 3 articles about tert-butyl 3-(1-(3-((hydroxydimethylsilyl)methyl)benzoyl)piperidin-4-yl)benzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.25%

: 51801-45-7
3-((hydroxydimethylsilyl)methyl)benzoic acid

: 725228-49-9
tert-butyl 3-(piperidin-4-yl)benzylcarbamate

: 1431289-50-7
tert-butyl 3-(1-(3-((hydroxydimethylsilyl)methyl)benzoyl)piperidin-4-yl)benzylcarbamate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 1431289-45-0
methyl 3-((hydroxydimethylsilyl)methyl)benzoate

: 1431289-50-7
tert-butyl 3-(1-(3-((hydroxydimethylsilyl)methyl)benzoyl)piperidin-4-yl)benzylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide; water / tetrahydrofuran / 7 h / 50 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 3 h / 20 °C

With dmap; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1129-28-8
3-methoxycarbonylbenzyl bromide

: 1431289-50-7
tert-butyl 3-(1-(3-((hydroxydimethylsilyl)methyl)benzoyl)piperidin-4-yl)benzylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: johnphos; palladium dichloride; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 12 h / 60 °C

1.2: 2 h / 20 °C

2.1: lithium hydroxide; water / tetrahydrofuran / 7 h / 50 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 3 h / 20 °C

With dmap; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium dichloride; lithium hydroxide; johnphos; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane;