Tert-butyl 3-(piperidin-4-yl)benzylcarbamate

Base Information

Chemical Name:Tert-butyl 3-(piperidin-4-yl)benzylcarbamate
CAS No.:725228-49-9
Molecular Formula:C17H26N2O2
Molecular Weight:290.406
Hs Code.:
DSSTox Substance ID:DTXSID80467773
Wikidata:Q82294841
Mol file:725228-49-9.mol

Synonyms:tert-butyl 3-(piperidin-4-yl)benzylcarbamate;725228-49-9;tert-butyl N-[(3-piperidin-4-ylphenyl)methyl]carbamate;SCHEMBL301842;DTXSID80467773;MRFONSPCWQUCAX-UHFFFAOYSA-N;tert-Butyl (3-(piperidin-4-yl)benzyl)carbamate;A905910;4-[3-(tert-Butoxycarbonylaminomethyl)phenyl]piperidine;(3-piperidin-4-yl-benzyl)carbamic acid tert-butyl ester;4-[3-(tert-butoxy-carbonylaminomethyl)phenyl]piperidine;(3-Piperidin-4-yl-benzyl)-carbamic acid tert-butyl ester

Suppliers and Price of Tert-butyl 3-(piperidin-4-yl)benzylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
tert-Butyl3-(piperidin-4-yl)benzylcarbamate 97%
1g
$ 1764.00

Matrix Scientific
tert-Butyl3-(piperidin-4-yl)benzylcarbamate 97%
250mg
$ 630.00

Total 3 raw suppliers

Chemical Property of Tert-butyl 3-(piperidin-4-yl)benzylcarbamate

Chemical Property:

Boiling Point:440.7±45.0 °C(Predicted)
PKA:12.23±0.46(Predicted)
PSA：53.85000
Density:1.045±0.06 g/cm3(Predicted)
LogP:3.71150
XLogP3:2.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:290.199428076
Heavy Atom Count:21
Complexity:332

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl3-(piperidin-4-yl)benzylcarbamate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NCC1=CC(=CC=C1)C2CCNCC2

Technology Process of Tert-butyl 3-(piperidin-4-yl)benzylcarbamate

There total 13 articles about Tert-butyl 3-(piperidin-4-yl)benzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 4-[3-(tert-butoxycarbonylamino-methyl)-phenyl]-piperidine-1-carboxylic acid 2-trimethylsilanyl-ethyl ester

: 725228-49-9
tert-butyl 3-(piperidin-4-yl)benzylcarbamate

Guidance literature:: 4-[3-(tert-butoxycarbonylamino-methyl)-phenyl]-piperidine-1-carboxylic acid 2-trimethylsilanyl-ethyl ester; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 - 50 ℃; for 5h;

With hydrogenchloride; In tetrahydrofuran; water;

With sodium hydroxide; In tetrahydrofuran; water;

Reference yield: 86.0%

: 864069-14-7
4-[3-(tert-butoxycarbonylaminomethyl)phenyl]piperidine acetic acid salt

: 725228-49-9
tert-butyl 3-(piperidin-4-yl)benzylcarbamate

Guidance literature:: 4-[3-(tert-butoxycarbonylaminomethyl)phenyl]piperidine acetic acid salt; With hydrogenchloride; In water;

With sodium hydroxide; In water;

Reference yield:

: 19099-93-5
benzyl 4-oxo-1-piperidinecarboxylate

: 725228-49-9
tert-butyl 3-(piperidin-4-yl)benzylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / hexane; tetrahydrofuran / 1 h / -78 °C

1.2: -78 - 20 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile; water / 1 h / 90 °C

3.1: sodium tetrahydroborate / nickel(II) chloride hexahydrate / methanol / 0 - 20 °C / Cooling with ice

4.1: hydrogen / palladium-on-charcoal / methanol / 1 h

With sodium tetrahydroborate; hydrogen; sodium carbonate; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; nickel(II) chloride hexahydrate; palladium-on-charcoal; In tetrahydrofuran; methanol; hexane; water; acetonitrile;