(3R,4R)-4-[1-(4-acetylphenyl)ethenyl]-3-hydroxy-1,1-cyclopentanedicarboxylic acid diethyl ester

Base Information

• Chemical Name: (3R,4R)-4-[1-(4-acetylphenyl)ethenyl]-3-hydroxy-1,1-cyclopentanedicarboxylic acid diethyl ester
• CAS No.: 1015445-31-4
• Molecular Formula: C₂₁H₂₆O₆
• Molecular Weight: 374.434

Synonyms:(3R,4R)-4-[1-(4-acetylphenyl)ethenyl]-3-hydroxy-1,1-cyclopentanedicarboxylic acid diethyl ester

Chemical Property of (3R,4R)-4-[1-(4-acetylphenyl)ethenyl]-3-hydroxy-1,1-cyclopentanedicarboxylic acid diethyl ester

Chemical Property:

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Technology Process of (3R,4R)-4-[1-(4-acetylphenyl)ethenyl]-3-hydroxy-1,1-cyclopentanedicarboxylic acid diethyl ester

There total 1 articles about (3R,4R)-4-[1-(4-acetylphenyl)ethenyl]-3-hydroxy-1,1-cyclopentanedicarboxylic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

4-acetylphenylboronic acid (149104-90-5) + diethyl 2-buta-2,3-dienyl-2-(2-oxoethyl)malonate → (3R,4R)-4-[1-(4-acetylphenyl)ethenyl]-3-hydroxy-1,1-cyclopentanedicarboxylic acid diethyl ester (1015445-31-4)

Guidance literature:

With (S)-SEGPHOS; palladium diacetate; In acetonitrile; at 20 ℃; for 24h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ol702966j

Reference yield:

(3R,4R)-4-[1-(4-acetylphenyl)ethenyl]-3-hydroxy-1,1-cyclopentanedicarboxylic acid diethyl ester (1015445-31-4) + R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid (20445-31-2) → C31H33F3O8 (1015445-41-6)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; Inert atmosphere;

DOI:10.1021/ol702966j

Reference yield:

(3R,4R)-4-[1-(4-acetylphenyl)ethenyl]-3-hydroxy-1,1-cyclopentanedicarboxylic acid diethyl ester (1015445-31-4) + (S)-Mosher acid (17257-71-5,20445-31-2,56135-03-6,81655-41-6) → C31H33F3O8 (1015445-42-7)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; Inert atmosphere;

DOI:10.1021/ol702966j

upstream raw materials:

4-acetylphenylboronic acid

Downstream raw materials:

C₃₁H₃₃F₃O₈

C₃₁H₃₃F₃O₈

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