4-(1-(5-chloro-2-(3-((2,4-difluorophenyl)amino)azetidin-1-yl)nicotinamido)cyclopropyl)benzoic acid

Base Information

Chemical Name:4-(1-(5-chloro-2-(3-((2,4-difluorophenyl)amino)azetidin-1-yl)nicotinamido)cyclopropyl)benzoic acid
CAS No.:1380751-17-6
Molecular Formula:C₂₅H₂₁ClF₂N₄O₃
Molecular Weight:498.917
Hs Code.:

Synonyms:4-(1-(5-chloro-2-(3-((2,4-difluorophenyl)amino)azetidin-1-yl)nicotinamido)cyclopropyl)benzoic acid

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Chemical Property of 4-(1-(5-chloro-2-(3-((2,4-difluorophenyl)amino)azetidin-1-yl)nicotinamido)cyclopropyl)benzoic acid

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Technology Process of 4-(1-(5-chloro-2-(3-((2,4-difluorophenyl)amino)azetidin-1-yl)nicotinamido)cyclopropyl)benzoic acid

There total 11 articles about 4-(1-(5-chloro-2-(3-((2,4-difluorophenyl)amino)azetidin-1-yl)nicotinamido)cyclopropyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1380754-94-8
methyl 4-(1-(5-chloro-2-(3-((2,4-difluorophenyl)amino)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate

: 1380751-17-6
4-(1-(5-chloro-2-(3-((2,4-difluorophenyl)amino)azetidin-1-yl)nicotinamido)cyclopropyl)benzoic acid

Guidance literature:: methyl 4-(1-(5-chloro-2-(3-((2,4-difluorophenyl)amino)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate; With water; sodium hydroxide; In 1,4-dioxane; at 60 ℃; for 12h;

With hydrogenchloride; In water; at 0 ℃; for 0.166667h; pH=2;

Reference yield:

: 345965-52-8
1-(4-bromophenyl)cyclopropanecarboxylic acid

: 1380751-17-6
4-(1-(5-chloro-2-(3-((2,4-difluorophenyl)amino)azetidin-1-yl)nicotinamido)cyclopropyl)benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine; diphenyl phosphoryl azide / toluene / 5 h / Molecular sieve; Reflux

2.1: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / N,N-dimethyl-formamide; methanol / 48 h / 80 °C / 30003 Torr

3.1: hydrogenchloride / ethyl acetate / 20 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-1H-benzotriazol hydrate / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 24 h / 20 °C

5.1: sodium hydroxide; water / 1,4-dioxane / 12 h / 60 °C

5.2: 0.17 h / 0 °C / pH 2

With hydrogenchloride; diphenyl phosphoryl azide; 1-hydroxy-1H-benzotriazol hydrate; 1,3-bis-(diphenylphosphino)propane; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; palladium diacetate; In 1,4-dioxane; methanol; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 360773-84-8
tert-butyl [1-(4-bromophenyl)-cyclopropyl]-carbamate

: 1380751-17-6
4-(1-(5-chloro-2-(3-((2,4-difluorophenyl)amino)azetidin-1-yl)nicotinamido)cyclopropyl)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / N,N-dimethyl-formamide; methanol / 48 h / 80 °C / 30003 Torr

2.1: hydrogenchloride / ethyl acetate / 20 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-1H-benzotriazol hydrate / N,N-dimethyl-formamide / 0.17 h / 20 °C

3.2: 24 h / 20 °C

4.1: sodium hydroxide; water / 1,4-dioxane / 12 h / 60 °C

4.2: 0.17 h / 0 °C / pH 2

With hydrogenchloride; 1-hydroxy-1H-benzotriazol hydrate; 1,3-bis-(diphenylphosphino)propane; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; palladium diacetate; In 1,4-dioxane; methanol; ethyl acetate; N,N-dimethyl-formamide;