345965-52-8

Basic information

• Product Name: 1-(4-BROMOPHENYL)CYCLOPROPANECARBOXYLIC ACID
• Synonyms: 1-(4-BROMOPHENYL)CYCLOPROPANECARBOXYLIC ACID;1-(4-BroMophenyl)-1-cyclopropanecarboxylic acid;Cyclopropanecarboxylic acid, 1-(4-broMophenyl)-;1-(4-broMophenyl)cyclopropane-1-carboxylic acid;EOS-60374
• CAS NO: 345965-52-8
• Molecular Formula: C₁₀H₉BrO₂
• Molecular Weight: 241.08
• Product Categories: pharmacetical;Carboxylic Acids;Carboxylic Acids;Ring Systems
• Mol File: 345965-52-8.mol
• Article Data: 34

Chemical Properties

• Boiling Point: 354.34 °C at 760 mmHg
• Flash Point: 168.099 °C
• Appearance: /
• Density: 1.671 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.64
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.14±0.20(Predicted)
• CAS DataBase Reference: 1-(4-BROMOPHENYL)CYCLOPROPANECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-BROMOPHENYL)CYCLOPROPANECARBOXYLIC ACID(345965-52-8)
• EPA Substance Registry System: 1-(4-BROMOPHENYL)CYCLOPROPANECARBOXYLIC ACID(345965-52-8)

Safety Data

• Hazardous Substances Data: 345965-52-8(Hazardous Substances Data)

Usage

General Description

1-(4-Bromophenyl)cyclopropanecarboxylic acid is a chemical compound with a cyclopropane ring and a carboxylic acid functional group. It consists of a cyclopropane ring attached to a phenyl group that has a bromine atom at the para position. The carboxylic acid group is also attached to the cyclopropane ring. 1-(4-Bromophenyl)cyclopropanecarboxylic acid is commonly used in the field of organic chemistry and may have applications in pharmaceuticals, agrochemicals, or materials science. Its unique structure and reactivity make it a valuable building block for the synthesis of more complex organic molecules.

InChI:InChI=1/C10H9BrO2/c11-8-3-1-7(2-4-8)10(5-6-10)9(12)13/h1-4H,5-6H2,(H,12,13)

Upstream product

• 133017-10-4 Butyl 2-(4-bromophenyl)acetate 
• 16532-79-9 4-Bromophenylacetonitrile 
• 107-04-0 1-Bromo-2-chloroethane 
• 106-93-4 ethylene dibromide 
• 124276-67-1 1-(4-bromophenyl)cyclopropanecarbonitrile 
• 107-21-1 ethylene glycol 
• 6120-95-2 1-phenyl-1-cyclopropane carboxylic acid 

Downstream Products

• 360773-84-8 tert-butyl [1-(4-bromophenyl)-cyclopropyl]-carbamate 
• 638220-35-6 1-(4-bromophenyl)-cyclopropanecarboxylic acid methyl ester 
• 1215205-50-7 ethyl 1-(4-bromophenyl)cyclopropane-1-carboxylate 
• 1257214-56-4 N-[1-(4-bromo-phenyl)-cyclopropanecarbonyl]-methanesulfonamide 
• 1380587-39-2 1-(4'-bromobiphenyl-4-yl)cyclopropanecarboxylic acid ethyl ester 
• 1426925-13-4 1-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxylmethyl)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)cyclopropanecarbaldehyde O-methyl oxime 
• 1147531-61-0 1-(4-bromophenyl)cyclopropane-1-carbaldehyde 
• 1426925-14-5 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropane carbaldehyde 
• 1426925-15-6 (2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-(1-formyl cyclopropyl)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 1426925-16-7 (2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-((4-(1-(methoxyimino)methyl)cyclopropyl)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 1403395-83-4 [8-methyl-3-(1-{4-[5-(pyrrolidin-1-ylcarbonyl)pyridin-2-yl]phenyl}cyclopropyl)-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepin-8-yl]methanol 
• 1403395-84-5 [8-methyl-3-(1-{4-[5-(morpholin-4-ylcarbonyl)pyridin-2-yl]phenyl}cyclopropyl)-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepin-8-yl]methanol 
• 1403396-92-8 8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-8-methyl-3-{1-[4-(1H-pyrazol-5-yl)phenyl]cyclopropyl}-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine 
• 1403395-88-9 (8-methyl-3-{1-[4-(1H-pyrazol-5-yl)phenyl]cyclopropyl}-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepin-8-yl)methanol 

Relevant articles and documents

Preparation method of arylcyclopropane compound

The present invention discloses a method for preparing an arylcyclopropane compound, 1.0eq phenylacetonitrile and 1.1eq 1-bromo-2-chloroethane as the starting material, N, N- dimethylacetamide as a solvent, solvent dosage of 10V, plus 2.5eq sodium hydride

Electrophilic Bromolactonization of Cyclopropyl Diesters Using Lewis Basic Chalcogenide Catalysts

An efficient and regioselective electrophilic bromolactonization of cyclopropylmethyl diesters using triphenylphosphine sulfide (Ph3PS) or diphenyl selenide (Ph2Se) as the Lewis basic chalcogenide catalyst has been developed. It was observed that Ph3PS favored the formation of anti-diastereomer and yielded the multi-functional γ-lactones. Interestingly, the diastereoselectivity was reversed when using Ph2Se as a catalyst where the syn-product instead of the anti-product was favored. (Figure presented.).

General and cost-effective synthesis of 1-heteroaryl/arylcycloalkylamines and their broad applications

A general and cost-effective route has been developed to synthesize 1-heteroarylsubstituted cycloalkylamines from readily available heteroarylacetate in good yields. This synthesis features a LHMDS promoted cyclization and one-pot hydrolysis/Curtius rearr