[1-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperidin-4-yl]-cyclohexyl-methanone; hydrochloride

Base Information

Chemical Name:[1-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperidin-4-yl]-cyclohexyl-methanone; hydrochloride
CAS No.:80024-82-4
Molecular Formula:C₂₂H₃₀N₄O₃*ClH
Molecular Weight:434.966
Hs Code.:

Synonyms:[1-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperidin-4-yl]-cyclohexyl-methanone; hydrochloride

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Chemical Property of [1-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperidin-4-yl]-cyclohexyl-methanone; hydrochloride

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Technology Process of [1-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperidin-4-yl]-cyclohexyl-methanone; hydrochloride

There total 7 articles about [1-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperidin-4-yl]-cyclohexyl-methanone; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 80030-68-8
N-(2-Cyano-4,5-dimethoxy-phenyl)-4-cyclohexanecarbonyl-piperidine-1-carboximidothioic acid methyl ester

: 80024-82-4
[1-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperidin-4-yl]-cyclohexyl-methanone; hydrochloride

Guidance literature:: With ammonium chloride; In formamide; at 120 ℃;
DOI:10.1021/jm00364a014

Reference yield:

: 931-50-0
cyclohexylmagnesium bromide

: 80024-82-4
[1-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperidin-4-yl]-cyclohexyl-methanone; hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / a) reflux, 3 h, b) RT, overnight

2: 1 N aq. HCl, H₂ / 10percent Pd/C / methanol / 760 Torr / Ambient temperature

3: 95 percent / dimethylformamide / 0 °C

4: 89 percent / calcium oxide / CHCl₃ / Heating

5: 65 percent / ammonium chloride / formamide / 120 °C

With hydrogenchloride; ammonium chloride; hydrogen; calcium oxide; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; formamide; N,N-dimethyl-formamide;
DOI:10.1021/jm00364a014

Reference yield:

: 62718-31-4
1-benzylpiperidine-4-carbonitrile

: 80024-82-4
[1-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperidin-4-yl]-cyclohexyl-methanone; hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / a) reflux, 3 h, b) RT, overnight

2: 1 N aq. HCl, H₂ / 10percent Pd/C / methanol / 760 Torr / Ambient temperature

3: 95 percent / dimethylformamide / 0 °C

4: 89 percent / calcium oxide / CHCl₃ / Heating

5: 65 percent / ammonium chloride / formamide / 120 °C

With hydrogenchloride; ammonium chloride; hydrogen; calcium oxide; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; formamide; N,N-dimethyl-formamide;
DOI:10.1021/jm00364a014