(3aR,5R,7aR)-5-Benzyloxymethyl-3a-(3,4-dimethoxy-phenyl)-hexahydro-pyrano[3,4-b]pyrrol-7-one

Base Information

Chemical Name:(3aR,5R,7aR)-5-Benzyloxymethyl-3a-(3,4-dimethoxy-phenyl)-hexahydro-pyrano[3,4-b]pyrrol-7-one
CAS No.:131652-98-7
Molecular Formula:C₂₃H₂₇NO₅
Molecular Weight:397.471
Hs Code.:

Synonyms:(3aR,5R,7aR)-5-Benzyloxymethyl-3a-(3,4-dimethoxy-phenyl)-hexahydro-pyrano[3,4-b]pyrrol-7-one

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Chemical Property of (3aR,5R,7aR)-5-Benzyloxymethyl-3a-(3,4-dimethoxy-phenyl)-hexahydro-pyrano[3,4-b]pyrrol-7-one

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Technology Process of (3aR,5R,7aR)-5-Benzyloxymethyl-3a-(3,4-dimethoxy-phenyl)-hexahydro-pyrano[3,4-b]pyrrol-7-one

There total 7 articles about (3aR,5R,7aR)-5-Benzyloxymethyl-3a-(3,4-dimethoxy-phenyl)-hexahydro-pyrano[3,4-b]pyrrol-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 131652-97-6
(3aR,5R,7aR)-1-Benzyl-5-benzyloxymethyl-3a-(3,4-dimethoxy-phenyl)-hexahydro-pyrano[3,4-b]pyrrol-7-one

: 131652-98-7
(3aR,5R,7aR)-5-Benzyloxymethyl-3a-(3,4-dimethoxy-phenyl)-hexahydro-pyrano[3,4-b]pyrrol-7-one

Guidance literature:: With hydrogen; palladium hydroxide - carbon; In methanol; for 8h; Ambient temperature;
DOI:10.1246/cl.1990.1239

Reference yield:

: 81309-80-0,81309-81-1
(R)-5-Benzyloxymethyl-3-(3,4-dimethoxy-phenyl)-dihydro-furan-2-one

: 131652-98-7
(3aR,5R,7aR)-5-Benzyloxymethyl-3a-(3,4-dimethoxy-phenyl)-hexahydro-pyrano[3,4-b]pyrrol-7-one

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / LiAlH₄ / tetrahydrofuran / 0.67 h / 0 °C

2: 94 percent / n-Bu₃P / tetrahydrofuran / 1 h / Ambient temperature

3: Et₃N / CH₂Cl₂ / 0.5 h / -10 °C

4: CH₂Cl₂ / 5 h / Ambient temperature

5: 100 percent / 30percent H₂O₂ / CH₂Cl₂ / 9 h / 0 deg C to r.t.

6: 85 percent / xylene / 0.33 h / 250 °C / sealed tube

7: 88 percent / H₂ / 20percent Pd(OH)2-C / methanol / 8 h / Ambient temperature

With lithium aluminium tetrahydride; tributylphosphine; hydrogen; dihydrogen peroxide; triethylamine; palladium hydroxide - carbon; In tetrahydrofuran; methanol; dichloromethane; xylene;
DOI:10.1246/cl.1990.1239

Reference yield:

: 131652-78-3,131723-78-9
(R)-5-Benzyloxy-2-(3,4-dimethoxy-phenyl)-pentane-1,4-diol

: 131652-98-7
(3aR,5R,7aR)-5-Benzyloxymethyl-3a-(3,4-dimethoxy-phenyl)-hexahydro-pyrano[3,4-b]pyrrol-7-one

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / n-Bu₃P / tetrahydrofuran / 1 h / Ambient temperature

2: Et₃N / CH₂Cl₂ / 0.5 h / -10 °C

3: CH₂Cl₂ / 5 h / Ambient temperature

4: 100 percent / 30percent H₂O₂ / CH₂Cl₂ / 9 h / 0 deg C to r.t.

5: 85 percent / xylene / 0.33 h / 250 °C / sealed tube

6: 88 percent / H₂ / 20percent Pd(OH)2-C / methanol / 8 h / Ambient temperature

With tributylphosphine; hydrogen; dihydrogen peroxide; triethylamine; palladium hydroxide - carbon; In tetrahydrofuran; methanol; dichloromethane; xylene;
DOI:10.1246/cl.1990.1239