N-(4-((4-(3-(3-tert-butyl-1-(4-(hydroxymethyl)phenyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)methyl)pyridin-2-yl)-2-methoxyacetamide

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Chemical Name:N-(4-((4-(3-(3-tert-butyl-1-(4-(hydroxymethyl)phenyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)methyl)pyridin-2-yl)-2-methoxyacetamide
CAS No.:1229649-45-9
Molecular Formula:C₃₄H₃₆N₆O₅
Molecular Weight:608.697
Hs Code.:

Synonyms:N-(4-((4-(3-(3-tert-butyl-1-(4-(hydroxymethyl)phenyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)methyl)pyridin-2-yl)-2-methoxyacetamide

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Chemical Property of N-(4-((4-(3-(3-tert-butyl-1-(4-(hydroxymethyl)phenyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)methyl)pyridin-2-yl)-2-methoxyacetamide

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Technology Process of N-(4-((4-(3-(3-tert-butyl-1-(4-(hydroxymethyl)phenyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)methyl)pyridin-2-yl)-2-methoxyacetamide

There total 14 articles about N-(4-((4-(3-(3-tert-butyl-1-(4-(hydroxymethyl)phenyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)methyl)pyridin-2-yl)-2-methoxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: N-(4-((4-(3-(3-tert-butyl-1-(4-((tert-butyl dimethylsilyloxy)methyl)phenyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)methyl)pyridin-2-yl)-2-methoxyacetamide

: 1229649-45-9
N-(4-((4-(3-(3-tert-butyl-1-(4-(hydroxymethyl)phenyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)methyl)pyridin-2-yl)-2-methoxyacetamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at -5 - 20 ℃; for 1h;

Reference yield:

: 1220627-32-6
4-((4-aminonaphthalen-1-yloxy)methyl)pyrimidin-2-amine

: 285984-25-0,1244948-94-4
3-tert-butyl-1-p-tolyl-1H-pyrazol-5-amine

: 1229649-45-9
N-(4-((4-(3-(3-tert-butyl-1-(4-(hydroxymethyl)phenyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)methyl)pyridin-2-yl)-2-methoxyacetamide

Guidance literature:: With CDI; In 2-Methylpentane; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; ethyl acetate;

Reference yield:

: 165807-05-6
4-(dimethoxymethyl)pyrimidin-2-amine

: 1229649-45-9
N-(4-((4-(3-(3-tert-butyl-1-(4-(hydroxymethyl)phenyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)methyl)pyridin-2-yl)-2-methoxyacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; sodium tetrahydroborate; NaOH / water; tetrahydrofuran; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; methanol

2: triphenylphosphine; DIAD / tetrahydrofuran; methanol

3: acetic acid / Pt/C

4: CDI / ethyl acetate; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; 2-Methylpentane

With hydrogenchloride; sodium tetrahydroborate; NaOH; CDI; DIAD; acetic acid; triphenylphosphine; Pt/C; In tetrahydrofuran; methanol; 2-Methylpentane; water; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; ethyl acetate;