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165807-05-6

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165807-05-6 Usage

Uses

4-Dimethoxymethylpyrimidin-2-ylamine is a useful research chemical.

Check Digit Verification of cas no

The CAS Registry Mumber 165807-05-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,5,8,0 and 7 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 165807-05:
(8*1)+(7*6)+(6*5)+(5*8)+(4*0)+(3*7)+(2*0)+(1*5)=146
146 % 10 = 6
So 165807-05-6 is a valid CAS Registry Number.
InChI:InChI=1/C7H11N3O2/c1-11-6(12-2)5-3-4-9-7(8)10-5/h3-4,6H,1-2H3,(H2,8,9,10)

165807-05-6Relevant articles and documents

Alkenyl Isocyanide Conjugate Additions: A Rapid Route to γ-Carbolines

Chepyshev, Sergiy V.,Lujan-Montelongo, J. Armando,Chao, Allen,Fleming, Fraser F.

, p. 4310 - 4313 (2017)

Isocyanides are exceptional building blocks, the wide deployment of which in multicomponent and metal-insertion reactions belies their limited availability. The first conjugate addition/alkylation to alkenyl isocyanides is described, which addresses this deficiency. An array of organolithiums, magnesiates, enolates, and metalated nitriles add conjugately to β- and β,β-disubstituted arylsulfonyl alkenyl isocyanides to rapidly assemble diverse isocyanide scaffolds. The intermediate metalated isocyanides are efficiently trapped with electrophiles to generate substituted isocyanides incorporating contiguous tri- and tetra-substituted centers. The substituted isocyanides are ideally functionalized for elaboration into synthetic targets as illustrated by the three-step synthesis of γ-carboline N-methyl ingenine B.

HETEROCYCLIC COMPOUNDS USED AS FGFR INHIBITORS

-

Paragraph 0171-0173, (2019/05/24)

The present invention relates to a heterocyclic compound, a pharmaceutical composition containing the same, a preparation method thereof, and use thereof as a fibroblast growth factor receptor (FGFR) inhibitor. The compound is a heterocyclic compound as shown in Formula I, or a pharmaceutically acceptable salt, prodrug, solvent compound, polymorph, isomer or stable isotopic derivative thereof. The present invention further relates to use of the compound for the treatment or prevention of related diseases which are FGFR-mediated such as cancer, and a method for applying the compound to treat said diseases.

Two new approaches towards the synthesis of annomontine using Pictet-Spengler and aza-Diels-Alder reactions

Naik, Nilesh H.,Sikder, Arun K.,Kusurkar, Radhika S.

supporting information, p. 3715 - 3717 (2013/07/05)

Two new routes were established for the synthesis of biologically active natural product annomontine utilizing Pictet-Spengler and aza-Diels-Alder reactions as key steps.

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