4-[4-(tert-butyl-dimethyl-silanyloxy)-1-(2-methyl-imidazol-1-yl)-butyl]-benzonitrile

Base Information

• Chemical Name: 4-[4-(tert-butyl-dimethyl-silanyloxy)-1-(2-methyl-imidazol-1-yl)-butyl]-benzonitrile
• CAS No.: 311823-29-7
• Molecular Formula: C₂₁H₃₁N₃OSi
• Molecular Weight: 369.582
• Mol file: 311823-29-7.mol

Synonyms:4-[4-(tert-butyl-dimethyl-silanyloxy)-1-(2-methyl-imidazol-1-yl)-butyl]-benzonitrile

Chemical Property of 4-[4-(tert-butyl-dimethyl-silanyloxy)-1-(2-methyl-imidazol-1-yl)-butyl]-benzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[4-(tert-butyl-dimethyl-silanyloxy)-1-(2-methyl-imidazol-1-yl)-butyl]-benzonitrile

There total 4 articles about 4-[4-(tert-butyl-dimethyl-silanyloxy)-1-(2-methyl-imidazol-1-yl)-butyl]-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-iodo-3-(tert-butyldimethylsilyloxy)propane (78878-05-4) + 4-(2-methyl-imidazol-1-ylmethyl)-benzonitrile (311823-19-5) → 4-[4-(tert-butyl-dimethyl-silanyloxy)-1-(2-methyl-imidazol-1-yl)-butyl]-benzonitrile (311823-29-7)

Guidance literature:

4-(2-methyl-imidazol-1-ylmethyl)-benzonitrile; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

1-iodo-3-(tert-butyldimethylsilyloxy)propane; In tetrahydrofuran; at -78 - 0 ℃; for 6h; Further stages.;

DOI:10.1021/ol0002424

Reference yield:

1-(t-Butyldimethylsilyloxy)-3-chloro-propane (89031-82-3) → 4-[4-(tert-butyl-dimethyl-silanyloxy)-1-(2-methyl-imidazol-1-yl)-butyl]-benzonitrile (311823-29-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 78 percent / NaI / acetone / 24 h / Heating

2.1: LiHMDS / tetrahydrofuran / 1 h / -78 °C

2.2: 87 percent / tetrahydrofuran / 6 h / -78 - 0 °C

With sodium iodide; lithium hexamethyldisilazane; In tetrahydrofuran; acetone; 1.1: Substitution / 2.1: Metallation / 2.2: Substitution;

DOI:10.1021/ol0002424

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 4-[4-(tert-butyl-dimethyl-silanyloxy)-1-(2-methyl-imidazol-1-yl)-butyl]-benzonitrile (311823-29-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 95 percent / imidazole / dimethylformamide / 18 h / 20 °C

2.1: 78 percent / NaI / acetone / 24 h / Heating

3.1: LiHMDS / tetrahydrofuran / 1 h / -78 °C

3.2: 87 percent / tetrahydrofuran / 6 h / -78 - 0 °C

With 1H-imidazole; sodium iodide; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; acetone; 1.1: silylation / 2.1: Substitution / 3.1: Metallation / 3.2: Substitution;

DOI:10.1021/ol0002424

upstream raw materials:

1-iodo-3-(tert-butyldimethylsilyloxy)propane

4-(2-methyl-imidazol-1-ylmethyl)-benzonitrile

1-(t-Butyldimethylsilyloxy)-3-chloro-propane

tert-butyldimethylsilyl chloride

Downstream raw materials:

4-[1-(2-methyl-imidazol-1-yl)-4-oxo-butyl]-benzonitrile