C₁₉H₁₇NO₃

Base Information

• Chemical Name: C₁₉H₁₇NO₃
• CAS No.: 1617519-00-2
• Molecular Formula: C₁₉H₁₇NO₃
• Molecular Weight: 307.349
• Mol file: 1617519-00-2.mol

Synonyms:C₁₉H₁₇NO₃

Chemical Property of C₁₉H₁₇NO₃

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of C₁₉H₁₇NO₃

There total 4 articles about C₁₉H₁₇NO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

3-[(Z)-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-phenylethenyl]oxazolidin-2-one + para-bromoacetophenone (99-90-1) → C19H17NO3 (1617519-00-2)

Guidance literature:

With palladium diacetate; potassium carbonate; triphenylphosphine; In tetrahydrofuran; for 6h; Reflux;

DOI:10.1039/c4ob00979g

Reference yield: 76.0%

3-(2-phenylethynyl)oxazolidin-2-one (888329-88-2) + 4-acetylphenylboronic acid (149104-90-5) → C19H17NO3 (1617519-00-2)

Guidance literature:

With palladium diacetate; sodium carbonate; tri(m-tolyl)phosphine; In 1,4-dioxane; at 70 ℃; for 4h; regioselective reaction; Inert atmosphere;

DOI:10.1021/jo501894j

Reference yield:

1-Bromo-2-phenylacetylene (932-87-6) → C19H17NO3 (1617519-00-2)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate; copper(ll) sulfate pentahydrate; 1,10-Phenanthroline / toluene / 80 °C

2: copper(l) chloride; sodium t-butanolate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene; methanol / 4.5 h / 20 °C / Schlenk technique; Inert atmosphere

3: potassium carbonate; palladium diacetate; triphenylphosphine / tetrahydrofuran / 6 h / Reflux

With 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; palladium diacetate; potassium carbonate; triphenylphosphine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; copper(l) chloride; sodium t-butanolate; In tetrahydrofuran; methanol; toluene;

DOI:10.1039/c4ob00979g

upstream raw materials:

para-bromoacetophenone

3-(2-phenylethynyl)oxazolidin-2-one

1-Bromo-2-phenylacetylene

4-acetylphenylboronic acid