ethyl (S)-4,5-dihydro-2-[2-hydroxy-4-[12-(tert-butoxycarbonylamino)-5,9-bis(tert-butoxycarbonyl)-5,9-diazadodecyloxy]phenyl]-4-methyl-4-thiazolecarboxylate

Base Information

Chemical Name:ethyl (S)-4,5-dihydro-2-[2-hydroxy-4-[12-(tert-butoxycarbonylamino)-5,9-bis(tert-butoxycarbonyl)-5,9-diazadodecyloxy]phenyl]-4-methyl-4-thiazolecarboxylate
CAS No.:847829-19-0
Molecular Formula:C₃₈H₆₂N₄O₁₀S
Molecular Weight:766.997
Hs Code.:

ethyl (S)-4,5-dihydro-2-[2-hydroxy-4-[12-(tert-butoxycarbonylamino)-5,9-bis(tert-butoxycarbonyl)-5,9-diazadodecyloxy]phenyl]-4-methyl-4-thiazolecarboxylate

Synonyms:ethyl (S)-4,5-dihydro-2-[2-hydroxy-4-[12-(tert-butoxycarbonylamino)-5,9-bis(tert-butoxycarbonyl)-5,9-diazadodecyloxy]phenyl]-4-methyl-4-thiazolecarboxylate

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Chemical Property of ethyl (S)-4,5-dihydro-2-[2-hydroxy-4-[12-(tert-butoxycarbonylamino)-5,9-bis(tert-butoxycarbonyl)-5,9-diazadodecyloxy]phenyl]-4-methyl-4-thiazolecarboxylate

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Technology Process of ethyl (S)-4,5-dihydro-2-[2-hydroxy-4-[12-(tert-butoxycarbonylamino)-5,9-bis(tert-butoxycarbonyl)-5,9-diazadodecyloxy]phenyl]-4-methyl-4-thiazolecarboxylate

There total 9 articles about ethyl (S)-4,5-dihydro-2-[2-hydroxy-4-[12-(tert-butoxycarbonylamino)-5,9-bis(tert-butoxycarbonyl)-5,9-diazadodecyloxy]phenyl]-4-methyl-4-thiazolecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 847829-15-6
ethyl (S)-2-(2,4-dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylate

: 847829-18-9
N¹,N⁴,N⁷-tris(tert-butoxycarbonyl)-N¹-[4-(tosyloxy)butyl]norspermidine

: 847829-19-0
ethyl (S)-4,5-dihydro-2-[2-hydroxy-4-[12-(tert-butoxycarbonylamino)-5,9-bis(tert-butoxycarbonyl)-5,9-diazadodecyloxy]phenyl]-4-methyl-4-thiazolecarboxylate

Guidance literature:: With sodium ethanolate; In ethanol; at 60 ℃; for 15h;
DOI:10.1021/jm048974f

Reference yield:

: 147875-12-5
(3-tert-butoxycarbonylaminobutyl)-(2-cyanoethyl)carbamic acid tert-butyl ester

: 847829-19-0
ethyl (S)-4,5-dihydro-2-[2-hydroxy-4-[12-(tert-butoxycarbonylamino)-5,9-bis(tert-butoxycarbonyl)-5,9-diazadodecyloxy]phenyl]-4-methyl-4-thiazolecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: aq. NaOH; H₂ / Raney Ni / ethanol / 12 h / 2585.74 - 2844.31 Torr

2.1: 11.38 g / CH₂Cl₂; H₂O / 12 h / 20 °C

3.1: sodium hydride / dimethylformamide / 1.75 h / 0 - 20 °C

3.2: 78 percent / dimethylformamide / 19 h

4.1: HBr; AcOH; phenol / CH₂Cl₂ / 12 h / 0 °C

5.1: 2.46 g / triethylamine / tetrahydrofuran; H₂O / 12 h / 20 °C

6.1: 92 percent / triethylamine / CH₂Cl₂ / 12 h / 20 °C

7.1: 67 percent / NaOEt / ethanol / 15 h / 60 °C

With sodium hydroxide; hydrogen bromide; hydrogen; sodium ethanolate; sodium hydride; acetic acid; triethylamine; phenol; nickel; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm048974f

Reference yield:

: 4-[3-(3-amino-propylamino)-propylamino]-butan-1-ol; compound with GENERIC INORGANIC NEUTRAL COMPONENT

: 847829-19-0
ethyl (S)-4,5-dihydro-2-[2-hydroxy-4-[12-(tert-butoxycarbonylamino)-5,9-bis(tert-butoxycarbonyl)-5,9-diazadodecyloxy]phenyl]-4-methyl-4-thiazolecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 2.46 g / triethylamine / tetrahydrofuran; H₂O / 12 h / 20 °C

2: 92 percent / triethylamine / CH₂Cl₂ / 12 h / 20 °C

3: 67 percent / NaOEt / ethanol / 15 h / 60 °C

With sodium ethanolate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/jm048974f