(S)-4,5-dihydro-2-[2-hydroxy-4-[12-(tert-butoxycarbonylamino)-5,9-bis(tert-butoxycarbonyl)-5,9-diazadodecyloxy]phenyl]-4-methyl-4-thiazolecarboxylic acid

Base Information

Chemical Name:(S)-4,5-dihydro-2-[2-hydroxy-4-[12-(tert-butoxycarbonylamino)-5,9-bis(tert-butoxycarbonyl)-5,9-diazadodecyloxy]phenyl]-4-methyl-4-thiazolecarboxylic acid
CAS No.:847829-20-3
Molecular Formula:C₃₆H₅₈N₄O₁₀S
Molecular Weight:738.943
Hs Code.:

(S)-4,5-dihydro-2-[2-hydroxy-4-[12-(tert-butoxycarbonylamino)-5,9-bis(tert-butoxycarbonyl)-5,9-diazadodecyloxy]phenyl]-4-methyl-4-thiazolecarboxylic acid

Synonyms:(S)-4,5-dihydro-2-[2-hydroxy-4-[12-(tert-butoxycarbonylamino)-5,9-bis(tert-butoxycarbonyl)-5,9-diazadodecyloxy]phenyl]-4-methyl-4-thiazolecarboxylic acid

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Chemical Property of (S)-4,5-dihydro-2-[2-hydroxy-4-[12-(tert-butoxycarbonylamino)-5,9-bis(tert-butoxycarbonyl)-5,9-diazadodecyloxy]phenyl]-4-methyl-4-thiazolecarboxylic acid

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Technology Process of (S)-4,5-dihydro-2-[2-hydroxy-4-[12-(tert-butoxycarbonylamino)-5,9-bis(tert-butoxycarbonyl)-5,9-diazadodecyloxy]phenyl]-4-methyl-4-thiazolecarboxylic acid

There total 11 articles about (S)-4,5-dihydro-2-[2-hydroxy-4-[12-(tert-butoxycarbonylamino)-5,9-bis(tert-butoxycarbonyl)-5,9-diazadodecyloxy]phenyl]-4-methyl-4-thiazolecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 847829-19-0
ethyl (S)-4,5-dihydro-2-[2-hydroxy-4-[12-(tert-butoxycarbonylamino)-5,9-bis(tert-butoxycarbonyl)-5,9-diazadodecyloxy]phenyl]-4-methyl-4-thiazolecarboxylate

: 847829-20-3
(S)-4,5-dihydro-2-[2-hydroxy-4-[12-(tert-butoxycarbonylamino)-5,9-bis(tert-butoxycarbonyl)-5,9-diazadodecyloxy]phenyl]-4-methyl-4-thiazolecarboxylic acid

Guidance literature:: With sodium hydroxide; water; In methanol;

Reference yield:

: 147875-12-5
(3-tert-butoxycarbonylaminobutyl)-(2-cyanoethyl)carbamic acid tert-butyl ester

: 847829-20-3
(S)-4,5-dihydro-2-[2-hydroxy-4-[12-(tert-butoxycarbonylamino)-5,9-bis(tert-butoxycarbonyl)-5,9-diazadodecyloxy]phenyl]-4-methyl-4-thiazolecarboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: aq. NaOH; H₂ / Raney Ni / ethanol / 12 h / 2585.74 - 2844.31 Torr

2.1: 11.38 g / CH₂Cl₂; H₂O / 12 h / 20 °C

3.1: sodium hydride / dimethylformamide / 1.75 h / 0 - 20 °C

3.2: 78 percent / dimethylformamide / 19 h

4.1: HBr; AcOH; phenol / CH₂Cl₂ / 12 h / 0 °C

5.1: 2.46 g / triethylamine / tetrahydrofuran; H₂O / 12 h / 20 °C

6.1: 92 percent / triethylamine / CH₂Cl₂ / 12 h / 20 °C

7.1: 67 percent / NaOEt / ethanol / 15 h / 60 °C

8.1: 63 percent / NaOH / methanol / 15 h / 20 °C

With sodium hydroxide; hydrogen bromide; hydrogen; sodium ethanolate; sodium hydride; acetic acid; triethylamine; phenol; nickel; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm048974f

Reference yield:

: 847829-15-6
ethyl (S)-2-(2,4-dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylate

: 847829-20-3
(S)-4,5-dihydro-2-[2-hydroxy-4-[12-(tert-butoxycarbonylamino)-5,9-bis(tert-butoxycarbonyl)-5,9-diazadodecyloxy]phenyl]-4-methyl-4-thiazolecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / NaOEt / ethanol / 15 h / 60 °C

2: 63 percent / NaOH / methanol / 15 h / 20 °C

With sodium hydroxide; sodium ethanolate; In methanol; ethanol;
DOI:10.1021/jm048974f