N-(2,4-difluorobenzyl)-4-(2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzamide

Base Information

Chemical Name:N-(2,4-difluorobenzyl)-4-(2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzamide
CAS No.:1403331-13-4
Molecular Formula:C₂₈H₂₃F₂N₅O₄S
Molecular Weight:563.585
Hs Code.:

Synonyms:N-(2,4-difluorobenzyl)-4-(2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzamide

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Chemical Property of N-(2,4-difluorobenzyl)-4-(2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzamide

Chemical Property:

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Technology Process of N-(2,4-difluorobenzyl)-4-(2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzamide

There total 9 articles about N-(2,4-difluorobenzyl)-4-(2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1539264-89-5
4-(2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzoic acid

: 72235-52-0
2,4-Difluoro-benzylamine

: 1403331-13-4
N-(2,4-difluorobenzyl)-4-(2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzamide

Guidance literature:: With potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 20 ℃; for 35h;

Reference yield:

: 450-88-4
1-bromo-4-fluoro-2-methoxybenzene

: 1403331-13-4
N-(2,4-difluorobenzyl)-4-(2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium thiomethoxide / N,N-dimethyl-formamide / 2 h / 65 °C

1.2: 3 h / 0 - 65 °C

2.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 1 h / 20 °C

3.1: chloro(2-dicyclohexylphosphino-2’,4’,6’-tri-i-propyl-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-t-butyl ether adduct; XPhos; potassium phosphate / toluene / 18 h / Inert atmosphere; Reflux

4.1: potassium carbonate; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride / propan-1-ol / 43.5 h / Reflux

5.1: potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 35 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; chloro(2-dicyclohexylphosphino-2’,4’,6’-tri-i-propyl-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-t-butyl ether adduct; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; XPhos; sodium thiomethoxide; In propan-1-ol; chloroform; N,N-dimethyl-formamide; toluene;

Reference yield:

: 67868-91-1
1-bromo-2-methoxy-4-(methylsulfanyl)benzene

: 1403331-13-4
N-(2,4-difluorobenzyl)-4-(2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 3-chloro-benzenecarboperoxoic acid / chloroform / 1 h / 20 °C

2: chloro(2-dicyclohexylphosphino-2’,4’,6’-tri-i-propyl-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-t-butyl ether adduct; XPhos; potassium phosphate / toluene / 18 h / Inert atmosphere; Reflux

3: potassium carbonate; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride / propan-1-ol / 43.5 h / Reflux

4: potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 35 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; chloro(2-dicyclohexylphosphino-2’,4’,6’-tri-i-propyl-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-t-butyl ether adduct; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; XPhos; In propan-1-ol; chloroform; N,N-dimethyl-formamide; toluene;