ethyl 2-(((11-fluoro-2-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-6-yl)methyl)amino)acetate

Base Information

Chemical Name:ethyl 2-(((11-fluoro-2-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-6-yl)methyl)amino)acetate
CAS No.:1427033-51-9
Molecular Formula:C₃₇H₃₃F₂N₅O₇S
Molecular Weight:729.761
Hs Code.:

ethyl 2-(((11-fluoro-2-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-6-yl)methyl)amino)acetate

Synonyms:ethyl 2-(((11-fluoro-2-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-6-yl)methyl)amino)acetate

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Chemical Property of ethyl 2-(((11-fluoro-2-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-6-yl)methyl)amino)acetate

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Technology Process of ethyl 2-(((11-fluoro-2-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-6-yl)methyl)amino)acetate

There total 25 articles about ethyl 2-(((11-fluoro-2-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-6-yl)methyl)amino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 924-44-7
glyoxylic acid ethyl ester

: 1427034-97-6
5-(6-(aminomethyl)-11-fluoro-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

: 1427033-51-9
ethyl 2-(((11-fluoro-2-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-6-yl)methyl)amino)acetate

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃;

Reference yield:

: 1426942-84-8
6-chloro-2-(4-fluoro-1H-indol-2-yl)pyridin-3-ol

: 1427033-51-9
ethyl 2-(((11-fluoro-2-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-6-yl)methyl)amino)acetate

Guidance literature:: Multi-step reaction with 9 steps

1: hydrogenchloride; tin / ethanol / 3 h / Reflux

2: methanesulfonic acid / tetrahydrofuran / 2 h / 50 °C

3: 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 2 h / 80 °C

4: sodium tetrahydroborate / dichloromethane; methanol / 2 h / 20 °C

5: pyridine / 2 h / 0 - 20 °C / Inert atmosphere

6: sodium azide / N,N-dimethyl-formamide / 6 h / 60 °C / Inert atmosphere

7: XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate tribasic trihydrate / 1,4-dioxane; water / 2 h / 90 °C / Inert atmosphere

8: hydrogen; 5%-palladium/activated carbon / methanol / 20 °C / 1551.49 Torr

9: acetic acid / dichloromethane / 1 h / 20 °C

With pyridine; hydrogenchloride; tin; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium azide; methanesulfonic acid; potassium phosphate tribasic trihydrate; 5%-palladium/activated carbon; hydrogen; acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1426942-85-9
6-chloro-2-(4-fluoroindolin-2-yl)pyridin-3-ol

: 1427033-51-9
ethyl 2-(((11-fluoro-2-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-6-yl)methyl)amino)acetate

Guidance literature:: Multi-step reaction with 8 steps

1: methanesulfonic acid / tetrahydrofuran / 2 h / 50 °C

2: 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 2 h / 80 °C

3: sodium tetrahydroborate / dichloromethane; methanol / 2 h / 20 °C

4: pyridine / 2 h / 0 - 20 °C / Inert atmosphere

5: sodium azide / N,N-dimethyl-formamide / 6 h / 60 °C / Inert atmosphere

6: XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate tribasic trihydrate / 1,4-dioxane; water / 2 h / 90 °C / Inert atmosphere

7: hydrogen; 5%-palladium/activated carbon / methanol / 20 °C / 1551.49 Torr

8: acetic acid / dichloromethane / 1 h / 20 °C

With pyridine; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium azide; methanesulfonic acid; potassium phosphate tribasic trihydrate; 5%-palladium/activated carbon; hydrogen; acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;