4-<4-chloro-2-<(2-fluorophenyl)hydroxymethyl>phenyl>-5-(N-phthalimidimethyl)-2H-1,2,3-triazole

Base Information

• Chemical Name: 4-<4-chloro-2-<(2-fluorophenyl)hydroxymethyl>phenyl>-5-(N-phthalimidimethyl)-2H-1,2,3-triazole
• CAS No.: 83948-86-1
• Molecular Formula: C₂₄H₁₆ClFN₄O₃
• Molecular Weight: 462.867

Synonyms:4-<4-chloro-2-<(2-fluorophenyl)hydroxymethyl>phenyl>-5-(N-phthalimidimethyl)-2H-1,2,3-triazole

Chemical Property of 4-<4-chloro-2-<(2-fluorophenyl)hydroxymethyl>phenyl>-5-(N-phthalimidimethyl)-2H-1,2,3-triazole

Chemical Property:

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Technology Process of 4-<4-chloro-2-<(2-fluorophenyl)hydroxymethyl>phenyl>-5-(N-phthalimidimethyl)-2H-1,2,3-triazole

There total 1 articles about 4-<4-chloro-2-<(2-fluorophenyl)hydroxymethyl>phenyl>-5-(N-phthalimidimethyl)-2H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-{4-chloro-2-[(2-fluorophenyl)hydroxymethyl]phenyl}-3-phthalimidopropyne (78131-62-1) → 4-<4-chloro-2-<(2-fluorophenyl)hydroxymethyl>phenyl>-5-(N-phthalimidimethyl)-2H-1,2,3-triazole (83948-86-1)

Guidance literature:

With sodium azide; acetic acid; In dimethyl sulfoxide; at 90 ℃; for 96h;

DOI:10.1021/jm00357a011

Reference yield: 60.0%

4-<4-chloro-2-<(2-fluorophenyl)hydroxymethyl>phenyl>-5-(N-phthalimidimethyl)-2H-1,2,3-triazole (83948-86-1) → 4-<4-chloro-2-(2-fuorobenzoyl)phenyl>-5--2H-1,2,3-triazole (83948-81-6)

Guidance literature:

With jones reagent; In acetone; for 1h; Ambient temperature;

DOI:10.1021/jm00357a011

Reference yield:

jones reagent + 4-<4-chloro-2-<(2-fluorophenyl)hydroxymethyl>phenyl>-5-(N-phthalimidimethyl)-2H-1,2,3-triazole (83948-86-1) → 4-<4-chloro-2-(2-fuorobenzoyl)phenyl>-5--2H-1,2,3-triazole (83948-81-6)

Guidance literature:

In dichloromethane; isopropyl alcohol; acetone;

upstream raw materials:

1-{4-chloro-2-[(2-fluorophenyl)hydroxymethyl]phenyl}-3-phthalimidopropyne

Downstream raw materials:

4-<4-chloro-2-(2-fuorobenzoyl)phenyl>-5--2H-1,2,3-triazole

8-Chloro-6-(2-fluorophenyl)-2H,4H-[1,2,3]triazolo[4,5-d][2]benzazepine

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