(2E,4E)-(R)-6-(tert-Butyl-diphenyl-silanyloxy)-tetradeca-2,4-dien-8-yn-1-ol

Base Information

Chemical Name:(2E,4E)-(R)-6-(tert-Butyl-diphenyl-silanyloxy)-tetradeca-2,4-dien-8-yn-1-ol
CAS No.:178060-98-5
Molecular Formula:C₃₀H₄₀O₂Si
Molecular Weight:460.732
Hs Code.:

Synonyms:(2E,4E)-(R)-6-(tert-Butyl-diphenyl-silanyloxy)-tetradeca-2,4-dien-8-yn-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2E,4E)-(R)-6-(tert-Butyl-diphenyl-silanyloxy)-tetradeca-2,4-dien-8-yn-1-ol

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Technology Process of (2E,4E)-(R)-6-(tert-Butyl-diphenyl-silanyloxy)-tetradeca-2,4-dien-8-yn-1-ol

There total 4 articles about (2E,4E)-(R)-6-(tert-Butyl-diphenyl-silanyloxy)-tetradeca-2,4-dien-8-yn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 178060-97-4
(2E,4E)-(R)-6-(tert-Butyl-diphenyl-silanyloxy)-tetradeca-2,4-dien-8-ynal

: 178060-98-5
(2E,4E)-(R)-6-(tert-Butyl-diphenyl-silanyloxy)-tetradeca-2,4-dien-8-yn-1-ol

Guidance literature:: With sodium tetrahydroborate; cerium(III) chloride; In isopropyl alcohol; at 0 ℃; for 6h;
DOI:10.1039/p19960001057

Reference yield:

: 178060-96-3
(9R,10S,11S,12R)-9,12-Bis-(tert-butyl-diphenyl-silanyloxy)-icosa-6,14-diyne-10,11-diol

: 178060-98-5
(2E,4E)-(R)-6-(tert-Butyl-diphenyl-silanyloxy)-tetradeca-2,4-dien-8-yn-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / Pb(OAc)4 / benzene / 2 h / Ambient temperature

2: K₂CO₃ / tetrahydrofuran; diethyl ether; H₂O / 24 h / Ambient temperature

3: 89 percent / NaBH₄, CeCl₃*7H₂O / propan-2-ol / 6 h / 0 °C

With lead(IV) acetate; sodium tetrahydroborate; cerium(III) chloride; potassium carbonate; In tetrahydrofuran; diethyl ether; water; isopropyl alcohol; benzene;
DOI:10.1039/p19960001057

Reference yield:

: 119414-22-1
9(R),12(R)-bis<(tert-butyldiphenylsilyl)oxy>-10(S),11(S)-O-(1-methylethylidene)-6,14-icosadiyne-10,11-diol

: 178060-98-5
(2E,4E)-(R)-6-(tert-Butyl-diphenyl-silanyloxy)-tetradeca-2,4-dien-8-yn-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / TiCl₄, Ph₃As, HS(CH₂)3SH / CH₂Cl₂ / 1.) -78 deg C, 1 h, 2.) r.t., 2 h

2: 74 percent / Pb(OAc)4 / benzene / 2 h / Ambient temperature

3: K₂CO₃ / tetrahydrofuran; diethyl ether; H₂O / 24 h / Ambient temperature

4: 89 percent / NaBH₄, CeCl₃*7H₂O / propan-2-ol / 6 h / 0 °C

With 1.3-propanedithiol; lead(IV) acetate; sodium tetrahydroborate; cerium(III) chloride; triphenyl-arsane; titanium tetrachloride; potassium carbonate; In tetrahydrofuran; diethyl ether; dichloromethane; water; isopropyl alcohol; benzene;
DOI:10.1039/p19960001057