4-(n-butylamino)-6-phenyl-8-methoxypyrimido[4,5-b][1,4]benzothiazepine 11-oxide

Base Information

• Chemical Name: 4-(n-butylamino)-6-phenyl-8-methoxypyrimido[4,5-b][1,4]benzothiazepine 11-oxide
• CAS No.: 929034-71-9
• Molecular Formula: C₂₂H₂₂N₄O₂S
• Molecular Weight: 406.508

Synonyms:4-(n-butylamino)-6-phenyl-8-methoxypyrimido[4,5-b][1,4]benzothiazepine 11-oxide

Chemical Property of 4-(n-butylamino)-6-phenyl-8-methoxypyrimido[4,5-b][1,4]benzothiazepine 11-oxide

Chemical Property:

Purity/Quality:

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Technology Process of 4-(n-butylamino)-6-phenyl-8-methoxypyrimido[4,5-b][1,4]benzothiazepine 11-oxide

There total 2 articles about 4-(n-butylamino)-6-phenyl-8-methoxypyrimido[4,5-b][1,4]benzothiazepine 11-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-(p-methoxyphenylthio)-6-phenyl-8-methoxypyrimido[4,5-b][1,4]benzothiazepine 11-oxide (929034-64-0) + N-butylamine (109-73-9,85404-21-3) → 4-(n-butylamino)-6-phenyl-8-methoxypyrimido[4,5-b][1,4]benzothiazepine 11-oxide (929034-71-9)

Guidance literature:

In dichloromethane; at 20 ℃; for 0.25h;

DOI:10.1021/ol0627146

Reference yield:

4-(p-methoxyphenylthio)-6-phenyl-8-methoxypyrimido[4,5-b][1,4]benzothiazepine (873106-52-6) → 4-(n-butylamino)-6-phenyl-8-methoxypyrimido[4,5-b][1,4]benzothiazepine 11-oxide (929034-71-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 53 percent / m-CPBA / CH₂Cl₂ / 8 h / 20 °C

2: 80 percent / CH₂Cl₂ / 0.25 h / 20 °C

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1021/ol0627146

Reference yield: 82.0%

4-(n-butylamino)-6-phenyl-8-methoxypyrimido[4,5-b][1,4]benzothiazepine 11-oxide (929034-71-9) → 4-(n-butylamino)-6-phenyl-8-methoxypyrimido[5,4-c]isoquinoline

Guidance literature:

In toluene; for 0.25h; Heating;

DOI:10.1021/ol0627146

upstream raw materials:

4-(p-methoxyphenylthio)-6-phenyl-8-methoxypyrimido[4,5-b][1,4]benzothiazepine 11-oxide

N-butylamine

4-(p-methoxyphenylthio)-6-phenyl-8-methoxypyrimido[4,5-b][1,4]benzothiazepine

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