5-(4-{4-[3-(N-t-butoxycarbonyl-N-methylamino)-4-(4-methyl-2-propyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzimidazol-6-ylcarbonylamino)phenylthio]-2-(N-t-butoxycarbonyl-N-methylamino)phenylaminocarbonylmethoxy}benzyl)thiazolidine-2,4-dione

Base Information

Chemical Name:5-(4-{4-[3-(N-t-butoxycarbonyl-N-methylamino)-4-(4-methyl-2-propyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzimidazol-6-ylcarbonylamino)phenylthio]-2-(N-t-butoxycarbonyl-N-methylamino)phenylaminocarbonylmethoxy}benzyl)thiazolidine-2,4-dione
CAS No.:1350440-52-6
Molecular Formula:C₆₂H₆₅N₁₁O₉S₂
Molecular Weight:1172.4
Hs Code.:

5-(4-{4-[3-(N-t-butoxycarbonyl-N-methylamino)-4-(4-methyl-2-propyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzimidazol-6-ylcarbonylamino)phenylthio]-2-(N-t-butoxycarbonyl-N-methylamino)phenylaminocarbonylmethoxy}benzyl)thiazolidine-2,4-dione

Synonyms:5-(4-{4-[3-(N-t-butoxycarbonyl-N-methylamino)-4-(4-methyl-2-propyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzimidazol-6-ylcarbonylamino)phenylthio]-2-(N-t-butoxycarbonyl-N-methylamino)phenylaminocarbonylmethoxy}benzyl)thiazolidine-2,4-dione

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Chemical Property of 5-(4-{4-[3-(N-t-butoxycarbonyl-N-methylamino)-4-(4-methyl-2-propyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzimidazol-6-ylcarbonylamino)phenylthio]-2-(N-t-butoxycarbonyl-N-methylamino)phenylaminocarbonylmethoxy}benzyl)thiazolidine-2,4-dione

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Technology Process of 5-(4-{4-[3-(N-t-butoxycarbonyl-N-methylamino)-4-(4-methyl-2-propyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzimidazol-6-ylcarbonylamino)phenylthio]-2-(N-t-butoxycarbonyl-N-methylamino)phenylaminocarbonylmethoxy}benzyl)thiazolidine-2,4-dione

There total 4 articles about 5-(4-{4-[3-(N-t-butoxycarbonyl-N-methylamino)-4-(4-methyl-2-propyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzimidazol-6-ylcarbonylamino)phenylthio]-2-(N-t-butoxycarbonyl-N-methylamino)phenylaminocarbonylmethoxy}benzyl)thiazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350442-00-0
di-(4-hydroxyamino-3-(N-t-butoxycarbonyl-N-methylamino)phenyl) sulfide

: 1350440-52-6
5-(4-{4-[3-(N-t-butoxycarbonyl-N-methylamino)-4-(4-methyl-2-propyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzimidazol-6-ylcarbonylamino)phenylthio]-2-(N-t-butoxycarbonyl-N-methylamino)phenylaminocarbonylmethoxy}benzyl)thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 26 h / 55 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 240 h / 20 °C

With palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 1350440-50-4
di-(4-amino-3-(N-t-butoxycarbonyl-N-methylamino)phenyl) sulfide

: 1350440-52-6
5-(4-{4-[3-(N-t-butoxycarbonyl-N-methylamino)-4-(4-methyl-2-propyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzimidazol-6-ylcarbonylamino)phenylthio]-2-(N-t-butoxycarbonyl-N-methylamino)phenylaminocarbonylmethoxy}benzyl)thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 240 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;

Reference yield:

: 299176-17-3
N-(2-nitro-5-chlorophenyl)-N-methylcarbamic acid t-butyl ester

: 1350440-52-6
5-(4-{4-[3-(N-t-butoxycarbonyl-N-methylamino)-4-(4-methyl-2-propyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzimidazol-6-ylcarbonylamino)phenylthio]-2-(N-t-butoxycarbonyl-N-methylamino)phenylaminocarbonylmethoxy}benzyl)thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1: potassium thioacetate / N,N-dimethyl-formamide / 8.5 h / 180 °C

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 72 h / 20 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 26 h / 55 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 h / 20 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 240 h / 20 °C

With palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium thioacetate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;