Technology Process of 15-(3-iodophenyl)pentadecanoic acid
There total 12 articles about 15-(3-iodophenyl)pentadecanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: H2SO4 / 6 h / Heating
2: 68 percent / pyridinium chlorochromate (PCC) / CH2Cl2 / 2 h / Ambient temperature
3: 48 percent / KOt-Bu / CH2Cl2 / 3 h / Ambient temperature
4: 91 percent / H2 / 5percent Pd/C / ethyl acetate / 4 h
5: 1) NaNO2, HCl, 2) KI, I2 / glacial acetic acid, H2O, 1) 45 min., 2) 2.1) < 10 deg C, 2.5 h, 2.2) RT, overnight
6: 61 percent / KOH / methanol
With
hydrogenchloride; potassium hydroxide; sulfuric acid; potassium tert-butylate; hydrogen; iodine; pyridinium chlorochromate; potassium iodide; sodium nitrite;
palladium on activated charcoal;
In
methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm00129a014
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 48 percent / KOt-Bu / CH2Cl2 / 3 h / Ambient temperature
2: 91 percent / H2 / 5percent Pd/C / ethyl acetate / 4 h
3: 1) NaNO2, HCl, 2) KI, I2 / glacial acetic acid, H2O, 1) 45 min., 2) 2.1) < 10 deg C, 2.5 h, 2.2) RT, overnight
4: 61 percent / KOH / methanol
With
hydrogenchloride; potassium hydroxide; potassium tert-butylate; hydrogen; iodine; potassium iodide; sodium nitrite;
palladium on activated charcoal;
In
methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm00129a014
