Technology Process of 1-acetyl-2-[15-(m-iodophenyl)pentadecanoyl]-rac-glycerol
There total 17 articles about 1-acetyl-2-[15-(m-iodophenyl)pentadecanoyl]-rac-glycerol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: H2SO4 / 6 h / Heating
2: 68 percent / pyridinium chlorochromate (PCC) / CH2Cl2 / 2 h / Ambient temperature
3: 48 percent / KOt-Bu / CH2Cl2 / 3 h / Ambient temperature
4: 91 percent / H2 / 5percent Pd/C / ethyl acetate / 4 h
5: 1) NaNO2, HCl, 2) KI, I2 / glacial acetic acid, H2O, 1) 45 min., 2) 2.1) < 10 deg C, 2.5 h, 2.2) RT, overnight
6: 61 percent / KOH / methanol
7: 66 percent / DMAP, DCC / CH2Cl2
8: 84 percent / 10percent H3BO3, silica gel / petroleum ether
With
hydrogenchloride; dmap; potassium hydroxide; sulfuric acid; potassium tert-butylate; hydrogen; iodine; boric acid; silica gel; dicyclohexyl-carbodiimide; pyridinium chlorochromate; potassium iodide; sodium nitrite;
palladium on activated charcoal;
In
methanol; dichloromethane; ethyl acetate; Petroleum ether;
DOI:10.1021/jm00129a014
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 68 percent / pyridinium chlorochromate (PCC) / CH2Cl2 / 2 h / Ambient temperature
2: 48 percent / KOt-Bu / CH2Cl2 / 3 h / Ambient temperature
3: 91 percent / H2 / 5percent Pd/C / ethyl acetate / 4 h
4: 1) NaNO2, HCl, 2) KI, I2 / glacial acetic acid, H2O, 1) 45 min., 2) 2.1) < 10 deg C, 2.5 h, 2.2) RT, overnight
5: 61 percent / KOH / methanol
6: 66 percent / DMAP, DCC / CH2Cl2
7: 84 percent / 10percent H3BO3, silica gel / petroleum ether
With
hydrogenchloride; dmap; potassium hydroxide; potassium tert-butylate; hydrogen; iodine; boric acid; silica gel; dicyclohexyl-carbodiimide; pyridinium chlorochromate; potassium iodide; sodium nitrite;
palladium on activated charcoal;
In
methanol; dichloromethane; ethyl acetate; Petroleum ether;
DOI:10.1021/jm00129a014
