2-butyl-4-chloro-5-(hydroxymethyl)-1-<<2-<2-(methoxycarbonyl)phenyl>furan-5-yl>methyl>-1H-imidazole

Base Information

Chemical Name:2-butyl-4-chloro-5-(hydroxymethyl)-1-<<2-<2-(methoxycarbonyl)phenyl>furan-5-yl>methyl>-1H-imidazole
CAS No.:164460-39-3
Molecular Formula:C₂₁H₂₃ClN₂O₄
Molecular Weight:402.878
Hs Code.:

Synonyms:2-butyl-4-chloro-5-(hydroxymethyl)-1-<<2-<2-(methoxycarbonyl)phenyl>furan-5-yl>methyl>-1H-imidazole

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Chemical Property of 2-butyl-4-chloro-5-(hydroxymethyl)-1-<<2-<2-(methoxycarbonyl)phenyl>furan-5-yl>methyl>-1H-imidazole

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Technology Process of 2-butyl-4-chloro-5-(hydroxymethyl)-1-<<2-<2-(methoxycarbonyl)phenyl>furan-5-yl>methyl>-1H-imidazole

There total 6 articles about 2-butyl-4-chloro-5-(hydroxymethyl)-1-<<2-<2-(methoxycarbonyl)phenyl>furan-5-yl>methyl>-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6630-33-7
ortho-bromobenzaldehyde

: 164460-39-3
2-butyl-4-chloro-5-(hydroxymethyl)-1-<<2-<2-(methoxycarbonyl)phenyl>furan-5-yl>methyl>-1H-imidazole

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / 5-(2-hydroxyethyl)-4-methyl-3-benzylthiazolium chloride, Et₃N / 4 h / 70 °C

2: 70 percent / 4 Angstroem molecular sieves, p-TsOH*H₂O / benzene / 12 h / Heating

3: n-BuLi / hexane; tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) RT, 3 h

4: 60 percent / diethyl ether

5: 80 percent / NBS, dibenzoyl peroxide / CCl₄ / 3 h / Heating

6: 1.) NaH / 1.) DMF, 1 h, 2.) DMF, 25 deg C, 16 h

With N-Bromosuccinimide; n-butyllithium; 4 A molecular sieve; 3-benzyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride; sodium hydride; toluene-4-sulfonic acid; triethylamine; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; diethyl ether; hexane; benzene;
DOI:10.1021/jm00049a012

Reference yield:

: 159448-54-1
2-(o-bromophenyl)-5-methylfuran

: 164460-39-3
2-butyl-4-chloro-5-(hydroxymethyl)-1-<<2-<2-(methoxycarbonyl)phenyl>furan-5-yl>methyl>-1H-imidazole

Guidance literature:: Multi-step reaction with 4 steps

1: n-BuLi / hexane; tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) RT, 3 h

2: 60 percent / diethyl ether

3: 80 percent / NBS, dibenzoyl peroxide / CCl₄ / 3 h / Heating

4: 1.) NaH / 1.) DMF, 1 h, 2.) DMF, 25 deg C, 16 h

With N-Bromosuccinimide; n-butyllithium; sodium hydride; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; diethyl ether; hexane;
DOI:10.1021/jm00049a012

Reference yield:

: 159448-53-0
1-(2-bromo-phenyl)-pentane-1,4-dione

: 164460-39-3
2-butyl-4-chloro-5-(hydroxymethyl)-1-<<2-<2-(methoxycarbonyl)phenyl>furan-5-yl>methyl>-1H-imidazole

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / 4 Angstroem molecular sieves, p-TsOH*H₂O / benzene / 12 h / Heating

2: n-BuLi / hexane; tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) RT, 3 h

3: 60 percent / diethyl ether

4: 80 percent / NBS, dibenzoyl peroxide / CCl₄ / 3 h / Heating

5: 1.) NaH / 1.) DMF, 1 h, 2.) DMF, 25 deg C, 16 h

With N-Bromosuccinimide; n-butyllithium; 4 A molecular sieve; sodium hydride; toluene-4-sulfonic acid; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; diethyl ether; hexane; benzene;
DOI:10.1021/jm00049a012