1,2-bis(5-(4-(bromomethyl)phenyl)-2-methylthiophen-3-yl)cyclopent-1-ene

Base Information

Chemical Name:1,2-bis(5-(4-(bromomethyl)phenyl)-2-methylthiophen-3-yl)cyclopent-1-ene
CAS No.:1449387-65-8
Molecular Formula:C₂₉H₂₆Br₂S₂
Molecular Weight:598.465
Hs Code.:

Synonyms:1,2-bis(5-(4-(bromomethyl)phenyl)-2-methylthiophen-3-yl)cyclopent-1-ene

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Chemical Property of 1,2-bis(5-(4-(bromomethyl)phenyl)-2-methylthiophen-3-yl)cyclopent-1-ene

Chemical Property:

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Technology Process of 1,2-bis(5-(4-(bromomethyl)phenyl)-2-methylthiophen-3-yl)cyclopent-1-ene

There total 4 articles about 1,2-bis(5-(4-(bromomethyl)phenyl)-2-methylthiophen-3-yl)cyclopent-1-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1380491-92-8
(4,4'-(4,4'-(cyclopentene-1,2-diyl)bis(5-methylthiophene-4,2-diyl))bis(4,1-phenylene))dimethanol

: 1449387-65-8
1,2-bis(5-(4-(bromomethyl)phenyl)-2-methylthiophen-3-yl)cyclopent-1-ene

Guidance literature:: With phosphorus tribromide; In dichloromethane; at 0 - 20 ℃; for 2h;
DOI:10.1002/cjoc.201300246

Reference yield:

: 509083-61-8
1,2-bis[5'-di-n-butoxyboryl-2'-methylthien-3'-yl]cyclopentene

: 1449387-65-8
1,2-bis(5-(4-(bromomethyl)phenyl)-2-methylthiophen-3-yl)cyclopent-1-ene

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ethylene glycol / water / 6 h / Reflux

2: pyridinium p-toluenesulfonate / water; acetone / 20 °C / Reflux; Inert atmosphere

3: potassium borohydride / ethanol; water / 1 h / 20 °C

4: phosphorus tribromide / dichloromethane / 2 h / 0 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium borohydride; pyridinium p-toluenesulfonate; phosphorus tribromide; sodium carbonate; ethylene glycol; In ethanol; dichloromethane; water; acetone; 1: |Suzuki Coupling;
DOI:10.1002/cjoc.201300246

Reference yield:

: 219537-97-0
1,2-bis(5-chloro-2-methylthien-3-yl)cyclopent-1-ene

: 1449387-65-8
1,2-bis(5-(4-(bromomethyl)phenyl)-2-methylthiophen-3-yl)cyclopent-1-ene

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ethylene glycol / water / 6 h / Reflux

3.1: pyridinium p-toluenesulfonate / water; acetone / 20 °C / Reflux; Inert atmosphere

4.1: potassium borohydride / ethanol; water / 1 h / 20 °C

5.1: phosphorus tribromide / dichloromethane / 2 h / 0 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; potassium borohydride; pyridinium p-toluenesulfonate; phosphorus tribromide; sodium carbonate; ethylene glycol; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; acetone; 2.1: |Suzuki Coupling;
DOI:10.1002/cjoc.201300246