(E)-1-[3,5-bis(trifluoromethyl)phenyl]ethanone O-benzyloxime

Base Information

Chemical Name:(E)-1-[3,5-bis(trifluoromethyl)phenyl]ethanone O-benzyloxime
CAS No.:1098069-30-7
Molecular Formula:C₁₇H₁₃F₆NO
Molecular Weight:361.287
Hs Code.:

Synonyms:(E)-1-[3,5-bis(trifluoromethyl)phenyl]ethanone O-benzyloxime

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Chemical Property of (E)-1-[3,5-bis(trifluoromethyl)phenyl]ethanone O-benzyloxime

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Technology Process of (E)-1-[3,5-bis(trifluoromethyl)phenyl]ethanone O-benzyloxime

There total 2 articles about (E)-1-[3,5-bis(trifluoromethyl)phenyl]ethanone O-benzyloxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 100-39-0
benzyl bromide

: (E)-1-(3,5-bis(trifluoromethyl)phenyl)ethanone oxime

: 1098069-30-7
(E)-1-[3,5-bis(trifluoromethyl)phenyl]ethanone O-benzyloxime

Guidance literature:: (E)-1-(3,5-bis(trifluoromethyl)phenyl)ethanone oxime; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

benzyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1021/jo400371x

Reference yield:

: 30071-93-3
3,5-bis(trifluoromethyl)phenyl methyl ketone

: 1098069-30-7
(E)-1-[3,5-bis(trifluoromethyl)phenyl]ethanone O-benzyloxime

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydroxylamine hydrochloride; sodium carbonate / ethanol; water / pH 5 / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

2.2: 18 h / 20 °C

With hydroxylamine hydrochloride; sodium hydride; sodium carbonate; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jo400371x

Reference yield:

: 1098069-30-7
(E)-1-[3,5-bis(trifluoromethyl)phenyl]ethanone O-benzyloxime

: 127733-40-8
(S)-α-(3,5-bis(trifluoromethyl)phenyl)ethylamine

Guidance literature:: With borane-THF; C₁₉H₂₃BNO₃^(1-)*H⁽¹⁺⁾; In 1,4-dioxane; for 72h; enantioselective reaction; Inert atmosphere;
DOI:10.1021/jo400371x