(S)-ethyl 2-(6-(5-(4-chlorophenylamino)pyridin-2-yl)-1-oxo-2-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydronaphthal-en-2-yl)acetate

Base Information

Chemical Name:(S)-ethyl 2-(6-(5-(4-chlorophenylamino)pyridin-2-yl)-1-oxo-2-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydronaphthal-en-2-yl)acetate
CAS No.:1609543-61-4
Molecular Formula:C₂₇H₂₄ClF₃N₂O₃
Molecular Weight:516.947
Hs Code.:

Synonyms:(S)-ethyl 2-(6-(5-(4-chlorophenylamino)pyridin-2-yl)-1-oxo-2-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydronaphthal-en-2-yl)acetate

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Chemical Property of (S)-ethyl 2-(6-(5-(4-chlorophenylamino)pyridin-2-yl)-1-oxo-2-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydronaphthal-en-2-yl)acetate

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Technology Process of (S)-ethyl 2-(6-(5-(4-chlorophenylamino)pyridin-2-yl)-1-oxo-2-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydronaphthal-en-2-yl)acetate

There total 12 articles about (S)-ethyl 2-(6-(5-(4-chlorophenylamino)pyridin-2-yl)-1-oxo-2-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydronaphthal-en-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1609543-76-1
ethyl 2-(6-(5-(4-chlorophenylamino)pyridin-2-yl)-1-oxo-2-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydronaphthal-en-2-yl)acetate

: 1609543-60-3
(R)-ethyl 2-(6-(5-(4-chlorophenylamino)pyridin-2-yl)-1-oxo-2-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydronaphthal-en-2-yl)acetate

: 1609543-61-4
(S)-ethyl 2-(6-(5-(4-chlorophenylamino)pyridin-2-yl)-1-oxo-2-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydronaphthal-en-2-yl)acetate

Guidance literature:: With CHIRAL PAK IA; In hexane; isopropyl alcohol; Resolution of racemate;

Reference yield:

: 1414798-33-6
ethyl 2-(6-hydroxy-1-oxo-2-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydronaphthalen-2-yl)acetate

: 1609543-60-3
(R)-ethyl 2-(6-(5-(4-chlorophenylamino)pyridin-2-yl)-1-oxo-2-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydronaphthal-en-2-yl)acetate

: 1609543-61-4
(S)-ethyl 2-(6-(5-(4-chlorophenylamino)pyridin-2-yl)-1-oxo-2-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydronaphthal-en-2-yl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / dichloromethane / 2 h / 20 °C / Cooling with ice

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 5 h / Inert atmosphere; Reflux

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / water; 1,4-dioxane / 6 h / Inert atmosphere; Reflux

4: iron; ammonium chloride / water; ethanol / 3 h / Reflux

5: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 5 h / 120 °C / Inert atmosphere; Sealed tube

6: CHIRAL PAK IA / hexane; isopropyl alcohol / Resolution of racemate

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; iron; ammonium chloride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; ethanol; hexane; dichloromethane; water; isopropyl alcohol; toluene;

Reference yield:

: 1414798-34-7
ethyl 2-(1-oxo-2-(2,2,2-trifluoroethyl)-6-(trifluoromethylsulfonyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)acetate

: 1609543-60-3
(R)-ethyl 2-(6-(5-(4-chlorophenylamino)pyridin-2-yl)-1-oxo-2-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydronaphthal-en-2-yl)acetate

: 1609543-61-4
(S)-ethyl 2-(6-(5-(4-chlorophenylamino)pyridin-2-yl)-1-oxo-2-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydronaphthal-en-2-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 5 h / Inert atmosphere; Reflux

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / water; 1,4-dioxane / 6 h / Inert atmosphere; Reflux

3: iron; ammonium chloride / water; ethanol / 3 h / Reflux

4: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 5 h / 120 °C / Inert atmosphere; Sealed tube

5: CHIRAL PAK IA / hexane; isopropyl alcohol / Resolution of racemate

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; iron; ammonium chloride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; ethanol; hexane; water; isopropyl alcohol; toluene;