3-(2-amino-1-methyl-ethyl)-1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:3-(2-amino-1-methyl-ethyl)-1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
CAS No.:618902-03-7
Molecular Formula:C₂₂H₂₃F₂N₃O₃
Molecular Weight:415.44
Hs Code.:

3-(2-amino-1-methyl-ethyl)-1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-1<i>H</i>-pyrimidine-2,4-dione

Synonyms:3-(2-amino-1-methyl-ethyl)-1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione

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Chemical Property of 3-(2-amino-1-methyl-ethyl)-1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione

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Technology Process of 3-(2-amino-1-methyl-ethyl)-1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione

There total 7 articles about 3-(2-amino-1-methyl-ethyl)-1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 618902-02-6
{2-[3-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-propyl}-carbamic acid tert-butyl ester

: 618902-03-7
3-(2-amino-1-methyl-ethyl)-1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jm030472z

Reference yield:

: 618902-01-5
3-[2-N-Boc-amino-1-(S)-methylethyl]-5-bromo-1-(2,6-difluorobenzyl)-6-methyluracil

: 618902-03-7
3-(2-amino-1-methyl-ethyl)-1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / Pd(PPh₃)4; aq. K₂CO₃ / toluene; ethanol / 18 h / 110 °C

2: 95 percent / TFA / CH₂Cl₂ / 1 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; trifluoroacetic acid; In ethanol; dichloromethane; toluene; 1: Suzuki coupling;
DOI:10.1021/jm030472z

Reference yield:

: 69385-30-4
2,6-difluorobenzylamine

: 618902-03-7
3-(2-amino-1-methyl-ethyl)-1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 7 steps

1: 79 percent / aq. HCl / Heating

2: 60 percent / pyridine / 24 h / 20 °C

3: 94 percent / AcOH / 1 h / Heating

4: 88 percent / Br₂; AcOH / 1 h / 20 °C

5: PPh₃; diethyl azodicarboxylate / tetrahydrofuran / 17 h / 20 °C

6: 90 percent / Pd(PPh₃)4; aq. K₂CO₃ / toluene; ethanol / 18 h / 110 °C

7: 95 percent / TFA / CH₂Cl₂ / 1 h / 20 °C

With pyridine; hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; potassium carbonate; acetic acid; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; toluene; 5: Mitsunobu reaction / 6: Suzuki coupling;
DOI:10.1021/jm030472z