2,11-bis<<(3,4-dimethoxyphenyl)methyl>amino>-6,8-dihydro-5H-pyrido<3',2':5,6>cyclohexa<1,2-b>pyrido<2',3':3,4>cyclopenta<1,2-e>pyridine-3,7,10-tricarboxylic acid triethyl ester

Base Information

Chemical Name:2,11-bis<<(3,4-dimethoxyphenyl)methyl>amino>-6,8-dihydro-5H-pyrido<3',2':5,6>cyclohexa<1,2-b>pyrido<2',3':3,4>cyclopenta<1,2-e>pyridine-3,7,10-tricarboxylic acid triethyl ester
CAS No.:155878-25-4
Molecular Formula:C₄₅H₄₇N₅O₁₀
Molecular Weight:817.896
Hs Code.:

2,11-bis<<(3,4-dimethoxyphenyl)methyl>amino>-6,8-dihydro-5H-pyrido<3',2':5,6>cyclohexa<1,2-b>pyrido<2',3':3,4>cyclopenta<1,2-e>pyridine-3,7,10-tricarboxylic acid triethyl ester

Synonyms:2,11-bis<<(3,4-dimethoxyphenyl)methyl>amino>-6,8-dihydro-5H-pyrido<3',2':5,6>cyclohexa<1,2-b>pyrido<2',3':3,4>cyclopenta<1,2-e>pyridine-3,7,10-tricarboxylic acid triethyl ester

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Chemical Property of 2,11-bis<<(3,4-dimethoxyphenyl)methyl>amino>-6,8-dihydro-5H-pyrido<3',2':5,6>cyclohexa<1,2-b>pyrido<2',3':3,4>cyclopenta<1,2-e>pyridine-3,7,10-tricarboxylic acid triethyl ester

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Technology Process of 2,11-bis<<(3,4-dimethoxyphenyl)methyl>amino>-6,8-dihydro-5H-pyrido<3',2':5,6>cyclohexa<1,2-b>pyrido<2',3':3,4>cyclopenta<1,2-e>pyridine-3,7,10-tricarboxylic acid triethyl ester

There total 7 articles about 2,11-bis<<(3,4-dimethoxyphenyl)methyl>amino>-6,8-dihydro-5H-pyrido<3',2':5,6>cyclohexa<1,2-b>pyrido<2',3':3,4>cyclopenta<1,2-e>pyridine-3,7,10-tricarboxylic acid triethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 155878-24-3
α-<2-<<(3,4-dimethoxyphenyl)methyl>amino>-5,6-dihydro-3-(ethoxycarbonyl)-7-oxo-5H-1-pyridin-6-yl>-α-<2-<<(3,4-dimethoxyphenyl)methyl>amino>-3-(ethoxycarbonyl)-8-oxo-5,6,7,8-tetrahydroquinolin-7-yl>acetic acid ethyl ester

: 155878-25-4
2,11-bis<<(3,4-dimethoxyphenyl)methyl>amino>-6,8-dihydro-5H-pyrido<3',2':5,6>cyclohexa<1,2-b>pyrido<2',3':3,4>cyclopenta<1,2-e>pyridine-3,7,10-tricarboxylic acid triethyl ester

Guidance literature:: With ammonium acetate; acetic acid; at 110 ℃; for 3h;
DOI:10.1021/ja00089a008

Reference yield:

: 1921-90-0
(E)-2-benzylidenecyclopentanone

: 155878-25-4
2,11-bis<<(3,4-dimethoxyphenyl)methyl>amino>-6,8-dihydro-5H-pyrido<3',2':5,6>cyclohexa<1,2-b>pyrido<2',3':3,4>cyclopenta<1,2-e>pyridine-3,7,10-tricarboxylic acid triethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 86 percent / 20 h / 40 - 45 °C

2: 32 percent / 2 N HCl / CH₂Cl₂

3: 53.9 percent / tetrahydrofuran / 8 h

4: 1.) OSO₄, 2.) NaIO₄ / 1.) THF, H₂O, t-BuOH, 20 min, 2.) THF, H₂O, t-BuOH, 24 h

5: TsOH / tetrahydrofuran / 23 h / Ambient temperature

6: 2.) 0.01 N HCl / 1.) THF, 40 deg, 12 h, 2.) THF, 8 h

7: 28 percent / NH₄OAc, AcOH / 3 h / 110 °C

With hydrogenchloride; sodium periodate; osmium(VIII) oxide; ammonium acetate; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00089a008

Reference yield:

: 3-benzylidene-2-oxocyclopentanecarboxaldehyde

: 155878-25-4
2,11-bis<<(3,4-dimethoxyphenyl)methyl>amino>-6,8-dihydro-5H-pyrido<3',2':5,6>cyclohexa<1,2-b>pyrido<2',3':3,4>cyclopenta<1,2-e>pyridine-3,7,10-tricarboxylic acid triethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 53.9 percent / tetrahydrofuran / 8 h

2: 1.) OSO₄, 2.) NaIO₄ / 1.) THF, H₂O, t-BuOH, 20 min, 2.) THF, H₂O, t-BuOH, 24 h

3: TsOH / tetrahydrofuran / 23 h / Ambient temperature

4: 2.) 0.01 N HCl / 1.) THF, 40 deg, 12 h, 2.) THF, 8 h

5: 28 percent / NH₄OAc, AcOH / 3 h / 110 °C

With hydrogenchloride; sodium periodate; osmium(VIII) oxide; ammonium acetate; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran;
DOI:10.1021/ja00089a008