1921-90-0Relevant articles and documents
Synthesis of unsymmetrical dienones with heteroaromatic substituents
Vatsadze,Sviridenkova,Manaenkova,Semashko,Zyk
, p. 2224 - 2225 (2005)
Condensation of heteroaromatic aldehydes with 2-benzylidenecyclopentanone in a basic medium afforded a number of unsymmetrical 2,5- diarylidenecyclopentanones. According to 1H NMR data, the dienones obtained were the E,E-isomers.
Design and Green Synthesis of Piperlongumine Analogs and Their Antioxidant Activity against Cerebral Ischemia-Reperfusion Injury
Li, Ge,Zheng, Yuantie,Yao, Jiali,Hu, Linya,Liu, Qunpeng,Ke, Furong,Feng, Weixiao,Zhao, Ya,Yan, Pencheng,He, Wenfei,Deng, Hui,Qiu, Peihong,Li, Wulan,Wu, Jianzhang
, p. 4545 - 4557 (2019)
The supplementation of exogenous antioxidants to scavenge excessive reactive oxygen species (ROS) is an effective treatment for cerebral ischemia-reperfusion injury (CIRI) in stroke. Piperlongumine (PL), a natural alkaloid, has a great potential as a neur
Ruthenium-catalysed synthesis of chiral exocyclic allylic alcoholsviachemoselective transfer hydrogenation of 2-arylidene cycloalkanones
Zhang, Kaili,Liu, Qixing,He, Renke,Chen, Danyi,Deng, Zhangshuang,Huang, Nianyu,Zhou, Haifeng
supporting information, p. 1628 - 1632 (2021/03/09)
An exclusive asymmetric reduction of C=O bonds of 2-arylidene four-, five-, six-, and seven-membered cycloalkanones has been studied systematically. The asymmetric transfer hydrogenation was performed using a robust and commercially available chiral diamine-derived ruthenium complex as a catalyst and HCOOH/Et3N as a hydrogen source under mild conditions, giving 51 examples of chiral exocyclic allylic alcohols in up to 96% yield and 99% ee. This method was also applicable to the gram-scale synthesis of the active intermediates of the anti-inflammatory loxoprofen and natural product (?)-goniomitine.
Metal- and Solvent-Free Transesterification and Aldol Condensation Reactions by a Homogenous Recyclable Basic Ionic Liquid Based on the 1,3,5-Triazine Framework
Hu, Yanqiu,Kazemnejadi, Milad,Ren, Mingqi
, p. 775 - 783 (2021/08/30)
A new recyclable basic ionic liquid was introduced as an efficient catalyst for aldol condensation and transesterification reactions under environmentally friendly conditions. The catalyst was prepared based on methyl imidazolium moieties bearing hydroxide counter anions via the Hofmann elimination on a 1,3,5-triazine framework. The ionic liquid with two functionalities including anion stabilizer and high basicity, was used as an efficient catalyst for aldol condensation as well as transesterification reaction of a variety of alkyl benzoates. All reactions were performed in the absence of any external reagent, co-catalyst, or solvent, in line with environmental protection. The kinetics isotope effect (KIE) was conducted for the transesterification reaction to elucidate the mechanism and rate determining step (RDS). It worth noted that, the homogeneous catalyst could be recycled from the reaction mixture and reused for several consecutive runs with insignificant drop of basicity and conversion.
