oxo-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-acetic acid methyl ester

Base Information

• Chemical Name: oxo-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-acetic acid methyl ester
• CAS No.: 615556-57-5
• Molecular Formula: C₁₈H₁₅NO₅S
• Molecular Weight: 357.387
• Mol file: 615556-57-5.mol

Synonyms:oxo-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-acetic acid methyl ester

Chemical Property of oxo-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of oxo-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-acetic acid methyl ester

There total 1 articles about oxo-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3-indolyl)oxoacetic acid methyl ester (18372-22-0) + p-toluenesulfonyl chloride (98-59-9) → oxo-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-acetic acid methyl ester (615556-57-5)

Guidance literature:

With sodium hydride; In acetonitrile;

DOI:10.1016/j.bmcl.2007.11.010

Reference yield: 91.0%

2,3-dimethyl-buta-1,3-diene (513-81-5) + oxo-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-acetic acid methyl ester (615556-57-5) → [2,3-dimethyl-9-(toluene-4-sulfonyl)-1,4,9,9a-tetrahydrocarbazol-4a-yl]oxoacetic acid methyl ester

Guidance literature:

In toluene; at 190 ℃; for 72h;

DOI:10.1021/jo034719b

Reference yield: 87.0%

allyl bromide (106-95-6) + oxo-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-acetic acid methyl ester (615556-57-5) → C21H21NO5S (1008781-07-4)

Guidance literature:

With indium; In tetrahydrofuran; water; at 0 ℃;

DOI:10.1016/j.bmcl.2007.11.010

upstream raw materials:

2-(3-indolyl)oxoacetic acid methyl ester

p-toluenesulfonyl chloride

Downstream raw materials:

C₂₁H₂₁NO₅S

C₁₈H₁₇NO₅S

C₂₀H₂₁NO₅S