3-[trans-2-(2-nitrophenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(5-fluorothiazol-2-yl)-benzamide

Base Information

Chemical Name:3-[trans-2-(2-nitrophenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(5-fluorothiazol-2-yl)-benzamide
CAS No.:1282519-42-9
Molecular Formula:C₂₂H₂₀FN₃O₅S
Molecular Weight:457.482
Hs Code.:

Synonyms:3-[trans-2-(2-nitrophenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(5-fluorothiazol-2-yl)-benzamide

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Chemical Property of 3-[trans-2-(2-nitrophenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(5-fluorothiazol-2-yl)-benzamide

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Technology Process of 3-[trans-2-(2-nitrophenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(5-fluorothiazol-2-yl)-benzamide

There total 10 articles about 3-[trans-2-(2-nitrophenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(5-fluorothiazol-2-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.4%

: 1282520-96-0
3-[(phosphonic acid diethyl ester)-methyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(5-fluorothiazol-2-yl)-benzamide

: 552-89-6
2-nitro-benzaldehyde

: 1282519-42-9
3-[trans-2-(2-nitrophenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(5-fluorothiazol-2-yl)-benzamide

Guidance literature:: With potassium hydroxide; 18-crown-6 ether; In dichloromethane; at 20 ℃; for 20h;

Reference yield:

: 13036-02-7
Dimethyl 5-hydroxyisophthalate

: 1282519-42-9
3-[trans-2-(2-nitrophenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(5-fluorothiazol-2-yl)-benzamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 0 - 20 °C

2.1: potassium hydroxide; methanol / 12 h / 100 °C

3.1: borane-THF / tetrahydrofuran / 12 h / 0 - 20 °C

3.2: 3 h / 0 °C

4.1: sodium hydroxide / tetrahydrofuran / 12 h / 20 °C

5.1: pyridine / dichloromethane / 2 h / 0 - 20 °C

6.1: thionyl chloride / 3 h / 100 °C

6.2: 12 h / 20 °C

7.1: sodium hydroxide / tetrahydrofuran / 12 h / 20 °C

8.1: tribromide phosphate / tetrahydrofuran / 12 h / 0 - 20 °C

9.1: 3 h / 160 °C

10.1: potassium hydroxide / 18-crown-6 ether / dichloromethane / 20 h / 20 °C

With pyridine; methanol; thionyl chloride; borane-THF; di-isopropyl azodicarboxylate; tribromide phosphate; triphenylphosphine; potassium hydroxide; sodium hydroxide; 18-crown-6 ether; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1282520-89-1
5-(2-methoxy-(1S)-methyl-ethoxy)isophthalic acid dimethyl ester

: 1282519-42-9
3-[trans-2-(2-nitrophenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(5-fluorothiazol-2-yl)-benzamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium hydroxide; methanol / 12 h / 100 °C

2.1: borane-THF / tetrahydrofuran / 12 h / 0 - 20 °C

2.2: 3 h / 0 °C

3.1: sodium hydroxide / tetrahydrofuran / 12 h / 20 °C

4.1: pyridine / dichloromethane / 2 h / 0 - 20 °C

5.1: thionyl chloride / 3 h / 100 °C

5.2: 12 h / 20 °C

6.1: sodium hydroxide / tetrahydrofuran / 12 h / 20 °C

7.1: tribromo phosphate / tetrahydrofuran / 12 h / 0 - 20 °C

8.1: 3 h / 160 °C

9.1: potassium hydroxide / 18-crown-6 ether / dichloromethane / 20 h / 20 °C

With pyridine; methanol; thionyl chloride; borane-THF; tribromo phosphate; potassium hydroxide; sodium hydroxide; 18-crown-6 ether; In tetrahydrofuran; dichloromethane;