3-[(phosphonic acid diethyl ester)-methyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(5-fluorothiazol-2-yl)-benzamide

Base Information

Chemical Name:3-[(phosphonic acid diethyl ester)-methyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(5-fluorothiazol-2-yl)-benzamide
CAS No.:1282520-96-0
Molecular Formula:C₁₉H₂₆FN₂O₆PS
Molecular Weight:460.463
Hs Code.:

Synonyms:3-[(phosphonic acid diethyl ester)-methyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(5-fluorothiazol-2-yl)-benzamide

Suppliers and Price of 3-[(phosphonic acid diethyl ester)-methyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(5-fluorothiazol-2-yl)-benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-[(phosphonic acid diethyl ester)-methyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(5-fluorothiazol-2-yl)-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-[(phosphonic acid diethyl ester)-methyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(5-fluorothiazol-2-yl)-benzamide

There total 6 articles about 3-[(phosphonic acid diethyl ester)-methyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(5-fluorothiazol-2-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.9%

: 1282521-06-5
3-bromomethyl-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(5-fluorothiazol-2-yl)-benzamide

: 122-52-1
triethyl phosphite

: 1282520-96-0
3-[(phosphonic acid diethyl ester)-methyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(5-fluorothiazol-2-yl)-benzamide

Guidance literature:: at 160 ℃; for 3h;

Reference yield:

: 1282520-99-3
3-hydroxymethyl-5-(2-methoxy-(1S)-methyl-ethoxy)-benzoic acid

: 1282520-96-0
3-[(phosphonic acid diethyl ester)-methyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(5-fluorothiazol-2-yl)-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / dichloromethane / 2 h / 0 - 20 °C

2.1: thionyl chloride / 3 h / 100 °C

2.2: 12 h / 20 °C

3.1: sodium hydroxide / tetrahydrofuran / 12 h / 20 °C

4.1: tribromo phosphate / tetrahydrofuran / 12 h / 0 - 20 °C

5.1: 3 h / 160 °C

With pyridine; thionyl chloride; tribromo phosphate; sodium hydroxide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1282520-90-4
5-(2-methoxy-(1S)-methyl-ethoxy)isophthalic acid monomethyl ester

: 1282520-96-0
3-[(phosphonic acid diethyl ester)-methyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(5-fluorothiazol-2-yl)-benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: borane-THF / tetrahydrofuran / 12 h / 0 - 20 °C

1.2: 3 h / 0 °C

2.1: sodium hydroxide / tetrahydrofuran / 12 h / 20 °C

3.1: pyridine / dichloromethane / 2 h / 0 - 20 °C

4.1: thionyl chloride / 3 h / 100 °C

4.2: 12 h / 20 °C

5.1: sodium hydroxide / tetrahydrofuran / 12 h / 20 °C

6.1: tribromo phosphate / tetrahydrofuran / 12 h / 0 - 20 °C

7.1: 3 h / 160 °C

With pyridine; thionyl chloride; borane-THF; tribromo phosphate; sodium hydroxide; In tetrahydrofuran; dichloromethane;