4-{(S)-2-[ethyl-(4-nitro-benzenesulfonyl)amino]-1-phenyl-ethylamino}quinazoline-8-carboxylic acid amide

Base Information

• Chemical Name: 4-{(S)-2-[ethyl-(4-nitro-benzenesulfonyl)amino]-1-phenyl-ethylamino}quinazoline-8-carboxylic acid amide
• CAS No.: 1240480-55-0
• Molecular Formula: C₂₅H₂₄N₆O₅S
• Molecular Weight: 520.569
• Mol file: 1240480-55-0.mol

Synonyms:4-{(S)-2-[ethyl-(4-nitro-benzenesulfonyl)amino]-1-phenyl-ethylamino}quinazoline-8-carboxylic acid amide

Chemical Property of 4-{(S)-2-[ethyl-(4-nitro-benzenesulfonyl)amino]-1-phenyl-ethylamino}quinazoline-8-carboxylic acid amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-{(S)-2-[ethyl-(4-nitro-benzenesulfonyl)amino]-1-phenyl-ethylamino}quinazoline-8-carboxylic acid amide

There total 10 articles about 4-{(S)-2-[ethyl-(4-nitro-benzenesulfonyl)amino]-1-phenyl-ethylamino}quinazoline-8-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

4-{(S)-2-[ethyl-(4-nitro-benzenesulfonyl)amino]-1-phenyl-ethylamino}quinazoline-8-carboxylic acid methyl ester (1240480-54-9) → 4-{(S)-2-[ethyl-(4-nitro-benzenesulfonyl)amino]-1-phenyl-ethylamino}quinazoline-8-carboxylic acid amide (1240480-55-0)

Guidance literature:

With ammonium hydroxide; In tetrahydrofuran; water; isopropyl alcohol; at 25 ℃; for 96h;

Reference yield:

4-oxo-3,4-dihydroquinazoline-8-carboxylic acid (19181-77-2) → 4-{(S)-2-[ethyl-(4-nitro-benzenesulfonyl)amino]-1-phenyl-ethylamino}quinazoline-8-carboxylic acid amide (1240480-55-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sulfuric acid / 48 h / Reflux

1.2: 20 °C / pH ~ 8

2.1: N-benzyl-N,N,N-triethylammonium chloride; N,N-dimethyl-aniline; trichlorophosphate / acetonitrile / 50 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 25 - 75 °C / Inert atmosphere

4.1: ammonium hydroxide / tetrahydrofuran; water; isopropyl alcohol / 96 h / 25 °C

With ammonium hydroxide; sulfuric acid; N-benzyl-N,N,N-triethylammonium chloride; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; water; isopropyl alcohol; acetonitrile;

Reference yield:

4-chloro-quinazoline-8-carboxylic acid methyl ester (903130-01-8) → 4-{(S)-2-[ethyl-(4-nitro-benzenesulfonyl)amino]-1-phenyl-ethylamino}quinazoline-8-carboxylic acid amide (1240480-55-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 25 - 75 °C / Inert atmosphere

2: ammonium hydroxide / tetrahydrofuran; water; isopropyl alcohol / 96 h / 25 °C

With ammonium hydroxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; isopropyl alcohol;

upstream raw materials:

4-{(S)-2-[ethyl-(4-nitro-benzenesulfonyl)amino]-1-phenyl-ethylamino}quinazoline-8-carboxylic acid methyl ester

4-oxo-3,4-dihydroquinazoline-8-carboxylic acid

4-chloro-quinazoline-8-carboxylic acid methyl ester

N-((S)-2-amino-2-phenyl-ethyl)-N-ethyl-4-nitro-benzenesulfonamide

Downstream raw materials:

4-((S)-2-ethylamino-1-phenyl-ethylamino)quinazoline-8-carboxylic acid amide