8-Quinazolinecarboxylic acid, 3,4-dihydro-4-oxo-

Base Information

• Chemical Name: 8-Quinazolinecarboxylic acid, 3,4-dihydro-4-oxo-
• CAS No.: 19181-77-2
• Molecular Formula: C9H6 N2 O3
• Molecular Weight: 190.158
• Hs Code.: 2933990090
• Mol file: 19181-77-2.mol

Synonyms:8-Quinazolinecarboxylic acid, 3,4-dihydro-4-oxo-

Chemical Property of 8-Quinazolinecarboxylic acid, 3,4-dihydro-4-oxo-

Chemical Property:

• Melting Point: 310-315 °C (decomp)
• Boiling Point: 428.9±47.0 °C(Predicted)
• PKA: 3.23±0.20(Predicted)
• PSA: 83.05000
• Density: 1.56±0.1 g/cm3(Predicted)
• LogP: 0.62130

Purity/Quality:

97% ^*data from raw suppliers

4-Oxo-3,4-dihydroquinazoline-8-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-Quinazolinecarboxylic acid, 3,4-dihydro-4-oxo-

There total 8 articles about 8-Quinazolinecarboxylic acid, 3,4-dihydro-4-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-aminoisophthalic acid (39622-79-2) + formamidine acetic acid (3473-63-0) + formamide (77287-34-4,77287-35-5,60100-09-6) → 4-hydroxyquinazoline-8-carboxylic acid (19181-77-2)

Guidance literature:

2-aminoisophthalic acid; formamidine acetic acid; for 0.416667h;

formamide; at 170 ℃; for 5h;

Reference yield: 87.0%

2-aminoisophthalic acid (39622-79-2) + formamidine acetic acid (3473-63-0) → 4-hydroxyquinazoline-8-carboxylic acid (19181-77-2)

Guidance literature:

With formamide; In methanol; at 170 ℃; for 5h; Inert atmosphere;

DOI:10.1021/jm300016v

Reference yield: 65.0%

4-oxo-4H-3,1-benzoxazine-8-carboxylic acid (1379546-43-6) → 4-oxo-3,4-dihydroquinazoline-8-carboxylic acid (19181-77-2)

Guidance literature:

4-oxo-4H-3,1-benzoxazine-8-carboxylic acid; With ammonium hydroxide; ammonium acetate; at 80 ℃; for 2h;

With methanol; at 80 ℃; for 72h; pressure bottle;

upstream raw materials:

2-aminoisophthalic acid

formamide

4-oxo-4H-3,1-benzoxazine-8-carboxylic acid

formaldehyd

Downstream raw materials:

4-[(S)-2-azetidin-1-yl-1-(3-fluorophenyl)-ethylamino]-quinazoline-8-carboxamide

4-((S)-2-dimethylamino-1-phenyl-ethylamino)-quinazoline-8-carboxamide

4-((S)-2-cyclopropylamino-1-phenyl-ethylamino)-quinazoline-8-carboxamide