Ethyl (E)-3-[4-(4-bromophenyl)phenyl]prop-2-enoate

Base Information

• Chemical Name: Ethyl (E)-3-[4-(4-bromophenyl)phenyl]prop-2-enoate
• CAS No.: 190729-08-9
• Molecular Formula: C₁₇H₁₅BrO₂
• Molecular Weight: 331.209
• Hs Code.: 2916399090
• Mol file: 190729-08-9.mol

Synonyms:(E)-3-(4'-Bromo-biphenyl-4-yl)-acrylic acid ethyl ester

Chemical Property of Ethyl (E)-3-[4-(4-bromophenyl)phenyl]prop-2-enoate

Chemical Property:

Purity/Quality:

Ethyl (E)-3-[4-(4-bromophenyl)phenyl]prop-2-enoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethyl (E)-3-[4-(4-bromophenyl)phenyl]prop-2-enoate

There total 2 articles about Ethyl (E)-3-[4-(4-bromophenyl)phenyl]prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-bromophenyl)bromobenzene (92-86-4) → (E)-3-(4'-Bromo-biphenyl-4-yl)-acrylic acid ethyl ester (190729-08-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 15 min, 2.) r.t., 2 h

2: 1.) NaOMe / 1.) DMF, r.t., 12 h, 2.) r.t., 48 h

With n-butyllithium; sodium methylate; In tetrahydrofuran; hexane;

DOI:10.1039/a607269k

Reference yield:

4-formyl-4'-bromobiphenyl (50670-58-1) + (ethoxycarbonylmethyl)triphenylphosphonium chloride (17577-28-5) → (E)-3-(4'-Bromo-biphenyl-4-yl)-acrylic acid ethyl ester (190729-08-9)

Guidance literature:

With sodium methylate; Yield given. Multistep reaction; 1.) DMF, r.t., 12 h, 2.) r.t., 48 h;

DOI:10.1039/a607269k

Reference yield:

(E)-3-(4'-Bromo-biphenyl-4-yl)-acrylic acid ethyl ester (190729-08-9) → 3-(4''-Bromobiphenyl-4'-yl)-1,2,3,4-tetrahydronaphthalen-1-one (60313-01-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) CuI, TMEDA, 2.) TMSCl / 1.) THF, -78 deg C, 15 min, -30 deg C, 24 h

2: 86 percent / AlCl₃ / toluene / 16 h / 90 °C

With copper(l) iodide; chloro-trimethyl-silane; aluminium trichloride; N,N,N,N,-tetramethylethylenediamine; In toluene;

DOI:10.1039/a607269k

upstream raw materials:

4-formyl-4'-bromobiphenyl

(ethoxycarbonylmethyl)triphenylphosphonium chloride

4-(4-bromophenyl)bromobenzene

Downstream raw materials:

3-(4'-Bromo-biphenyl-4-yl)-4-phenyl-butyric acid ethyl ester

(S)-3-(4'-Bromo-biphenyl-4-yl)-3,4-dihydro-2H-naphthalen-1-one

(R)-3-(4'-Bromo-biphenyl-4-yl)-3,4-dihydro-2H-naphthalen-1-one

(4S,5R)-1-[(E)-3-(4'-Bromo-biphenyl-4-yl)-acryloyl]-3,4-dimethyl-5-phenyl-imidazolidin-2-one

Refernces