60313-01-1

Basic information

• Product Name: 3-(4'-bromo[1,1'-biphenyl]-4-yl)-3,4-dihydronaphthalen-1(2H)-one
• Synonyms: 3-(4'-bromo[1,1'-biphenyl]-4-yl)-3,4-dihydronaphthalen-1(2H)-one;Einecs 262-162-0
• CAS NO: 60313-01-1
• Molecular Formula: C₂₂H₁₇BrO
• Molecular Weight: 377.27378
• EINECS: 262-162-0
• Mol File: 60313-01-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(4'-bromo[1,1'-biphenyl]-4-yl)-3,4-dihydronaphthalen-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4'-bromo[1,1'-biphenyl]-4-yl)-3,4-dihydronaphthalen-1(2H)-one(60313-01-1)
• EPA Substance Registry System: 3-(4'-bromo[1,1'-biphenyl]-4-yl)-3,4-dihydronaphthalen-1(2H)-one(60313-01-1)

Safety Data

• Hazardous Substances Data: 60313-01-1(Hazardous Substances Data)

Usage

General Description

3-(4'-bromo[1,1'-biphenyl]-4-yl)-3,4-dihydronaphthalen-1(2H)-one is a chemical compound with a complex molecular structure. It contains a naphthalene ring system with a brominated biphenyl substituent. 3-(4'-bromo[1,1'-biphenyl]-4-yl)-3,4-dihydronaphthalen-1(2H)-one belongs to the class of organic compounds known as phenyl naphthalenes. Its molecular formula is C22H17BrO, and it has a molecular weight of 373.277 g/mol. This chemical may have potential applications in the field of organic synthesis and pharmaceuticals, although further research is needed to fully understand its properties and potential uses.

Upstream product

• 60313-17-9 4'-bromo-α-(phenylmethyl)(1,1'-biphenyl)-4-methanol 
• 60313-31-7 4-bromo-4'-(1-bromo-2-phenylethyl)-1,1'-biphenyl 
• 92-66-0 4-bromo-1,1'-biphenyl 
• 6921-34-2 benzylmagnesium chloride 
• 190729-08-9 (E)-3-(4'-Bromo-biphenyl-4-yl)-acrylic acid ethyl ester 
• 50670-58-1 4-formyl-4'-bromobiphenyl 
• 92-86-4 4-(4-bromophenyl)bromobenzene 
• 124325-88-8 3-(4'-bromo-biphenyl-4-yl)-3-hydroxy-4-phenyl-butyric acid ethyl ester 
• 103-80-0 phenylacetyl chloride 
• 60312-95-0 1-[4'-bromo(1,1'-biphenyl)-4-yl]-2-phenylethan-1-one 
• 124325-89-9 3-(4'-Bromo-biphenyl-4-yl)-4-phenyl-butyric acid 
• 124325-90-2 3-(4'-Bromo-biphenyl-4-yl)-4-phenyl-butyric acid ethyl ester 
• 60313-47-5 {1-[4'-bromo(1,1'-biphenyl)-4-yl]-2-phenylethyl}malonic acid 

Downstream Products

• 70942-04-0 1-Bromo-3-(4'-bromo-biphenyl-4-yl)-1,2,3,4-tetrahydro-naphthalene 
• 56181-82-9 (+/-)-cis/trans-3-(4''-Bromobiphenyl-4'-yl)-1,2,3,4-tetrahydronaphthalen-1-ol 

Relevant articles and documents

Synthesis and antitumor activity of 4-hydroxycoumarin derivatives

A series of 4-hydroxycoumarin derivatives was prepared and evaluated for antitumor activity against five human tumor cell lines. A series of 4-hydroxycoumarin derivatives was prepared and evaluated for antitumor activity. The key fragments were 2a-c, 5c, 12b, 13b, 17, and 18 which were prepared via dianion ring cyclization, Friedel-Crafts acylation, and Reformatsky reaction. Compound 20b showed the most potent antitumor activity among the total 12 derivatives and compounds 19a and 19b exhibited efficacy comparable to etoposide in vitro antitumor activity.

Process for the preparation of 3-(4'-bromobiphenyl-4-yl)tetralin-1-one

A new process for the preparation of a 3-(4'-bromobiphenyl-4-yl)tetralin-1-one known as a key intermediate for the production of rodenticides and clinical medicines is provided. The title compound is prepared from P-bromobiphenylbenzylketone in three steps, wherein one of key inventions is dehydroxylation of 3-(4'-bromobiphenyl)-3-hydroxy-4-phenylbutyric acid ethyl ester using trialkylsilane in trifluoroacetic acid. This new process offers a high yield with a facile way and is more suitable for a commercial production than the prior art methods.