C₁₂H₁₁N₃O₂

Base Information

Chemical Name:C₁₂H₁₁N₃O₂
CAS No.:1578263-92-9
Molecular Formula:C₁₂H₁₁N₃O₂
Molecular Weight:229.238
Hs Code.:

C<sub>12</sub>H<sub>11</sub>N<sub>3</sub>O<sub>2</sub>

Synonyms:C₁₂H₁₁N₃O₂

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Chemical Property of C₁₂H₁₁N₃O₂

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Technology Process of C₁₂H₁₁N₃O₂

There total 1 articles about C₁₂H₁₁N₃O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5435-54-1
4-hydroxy-3-nitropyridine

: 1578263-92-9
C₁₂H₁₁N₃O₂

Guidance literature:: Multi-step reaction with 14 steps

1.1: bromine / water / 2 h / 50 °C

2.1: trichlorophosphate; diethylamine / 3 h / 0 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.2: 1 h / 20 °C

3.3: 16 h / Reflux

4.1: N,N-dimethyl acetamide / 2 h / 90 °C

5.1: acetic acid; iron / 2 h / Reflux

6.1: triethylamine / dichloromethane / 0.17 h

6.2: 2 h / 20 °C

7.1: sodium hydroxide; copper(II) sulfate; copper bronze / water / 16 h / 160 °C

8.1: triethylamine / tetrahydrofuran; water / 2 h / 20 °C

9.1: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 20 °C / 7757.43 Torr

10.1: piperidine / dichloromethane / 12 h / 20 °C

11.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C

12.1: dmap / N,N-dimethyl acetamide / 0.08 h / 20 °C / Microwave irradiation

13.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride / dimethyl amine / 1 h / 160 °C / Microwave irradiation

14.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 0 °C

14.2: 16.33 h / 20 °C

With piperidine; dmap; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; copper bronze; palladium 10% on activated carbon; hydrogen; bromine; iron; sodium hydride; copper(II) sulfate; acetic acid; diethylamine; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide; water; dimethyl amine; N,N-dimethyl-formamide;
DOI:10.1021/jm401625b