(1R,3S,4R)-3-(hydroxymethyl)-4-(methoxymethoxy)-2,2,4-trimethylcyclohexanol

Base Information

Chemical Name:(1R,3S,4R)-3-(hydroxymethyl)-4-(methoxymethoxy)-2,2,4-trimethylcyclohexanol
CAS No.:1566571-13-8
Molecular Formula:C₁₂H₂₄O₄
Molecular Weight:232.32
Hs Code.:

Synonyms:(1R,3S,4R)-3-(hydroxymethyl)-4-(methoxymethoxy)-2,2,4-trimethylcyclohexanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,3S,4R)-3-(hydroxymethyl)-4-(methoxymethoxy)-2,2,4-trimethylcyclohexanol

Chemical Property:

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Technology Process of (1R,3S,4R)-3-(hydroxymethyl)-4-(methoxymethoxy)-2,2,4-trimethylcyclohexanol

There total 3 articles about (1R,3S,4R)-3-(hydroxymethyl)-4-(methoxymethoxy)-2,2,4-trimethylcyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1566571-21-8
(1R,2R,5R)-2-(methoxymethoxy)-2,8,8-trimethyl-6-oxabicyclo[3.2.1]octan-7-one

: 1566571-13-8
(1R,3S,4R)-3-(hydroxymethyl)-4-(methoxymethoxy)-2,2,4-trimethylcyclohexanol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 0 - 20 ℃; for 3h;
DOI:10.1021/jo402572b

Reference yield:

: 105996-77-8
(1R,5R)-(-)-8,8-dimethyl-6-oxabicyclo<3.2.1>octane-2,7-dione

: 1566571-13-8
(1R,3S,4R)-3-(hydroxymethyl)-4-(methoxymethoxy)-2,2,4-trimethylcyclohexanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: cerium(III) chloride heptahydrate / tetrahydrofuran; diethyl ether / 1 h / -78 °C / Inert atmosphere

1.2: 12 h / -78 - 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 48 h / 0 - 20 °C

3.1: lithium aluminium tetrahydride / diethyl ether / 3 h / 0 - 20 °C

With lithium aluminium tetrahydride; cerium(III) chloride heptahydrate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jo402572b

Reference yield:

: 1566571-12-7
(1R,2R,5R)-2-hydroxy-2,8,8-trimethyl-6-oxabicyclo[3.2.1]-octan-7-one

: 1566571-13-8
(1R,3S,4R)-3-(hydroxymethyl)-4-(methoxymethoxy)-2,2,4-trimethylcyclohexanol

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 48 h / 0 - 20 °C

2: lithium aluminium tetrahydride / diethyl ether / 3 h / 0 - 20 °C

With lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane;
DOI:10.1021/jo402572b