Technology Process of 4-((1R,3R,6R)-3-hydroxy-6-(methoxymethoxy)-2,2,6-trimethylcyclohexyl)butan-2-one
There total 6 articles about 4-((1R,3R,6R)-3-hydroxy-6-(methoxymethoxy)-2,2,6-trimethylcyclohexyl)butan-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen;
In
methanol;
at 0 ℃;
for 3h;
DOI:10.1021/jo402572b
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: cerium(III) chloride heptahydrate / tetrahydrofuran; diethyl ether / 1 h / -78 °C / Inert atmosphere
1.2: 12 h / -78 - 20 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 48 h / 0 - 20 °C
3.1: lithium aluminium tetrahydride / diethyl ether / 3 h / 0 - 20 °C
4.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; tetrabutyl-ammonium chloride; sodium hypochlorite; potassium bromide / dichloromethane; water / 0 - 20 °C
5.1: toluene / 48 h / 130 °C / Inert atmosphere
6.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 0 °C
With
sodium hypochlorite; lithium aluminium tetrahydride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; cerium(III) chloride heptahydrate; palladium 10% on activated carbon; tetrabutyl-ammonium chloride; hydrogen; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; potassium bromide;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; toluene;
5.1: |Wittig Olefination;
DOI:10.1021/jo402572b
- Guidance literature:
-
Multi-step reaction with 4 steps
1: lithium aluminium tetrahydride / diethyl ether / 3 h / 0 - 20 °C
2: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; tetrabutyl-ammonium chloride; sodium hypochlorite; potassium bromide / dichloromethane; water / 0 - 20 °C
3: toluene / 48 h / 130 °C / Inert atmosphere
4: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 0 °C
With
sodium hypochlorite; lithium aluminium tetrahydride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; palladium 10% on activated carbon; tetrabutyl-ammonium chloride; hydrogen; sodium hydrogencarbonate; potassium bromide;
In
methanol; diethyl ether; dichloromethane; water; toluene;
3: |Wittig Olefination;
DOI:10.1021/jo402572b
